Abstract Background Ulcerative colitis (UC) is characterized by chronic intestinal inflammation. Histological remission has become an efficacy outcome in clinical trials and might have the potential to modify course of UC. Quantitative phase imaging including digital holographic microscopy (DHM) can be used for objective automated evaluation tissue morphology density. Our study aimed evaluate D...

In this paper, we apply a digital holographic microscope (DHM) in conjunction with stroboscopic acquisition synchronization. Here, the temperature-dependent decrease of the first resonance frequency (S₁(T)) and Young's elastic modulus (E₁(T)) of silicon micromechanical cantilever sensors (MCSs) are measured. To perform these measurements, the MCSs are uniformly heated from T₀ = 298 K to T = 450...

Aim of the study was to assess dihydrocodeine (DHC) and metabolites concentrations and their correlations with DHC analgesia in cancer patients with pain. Thirty opioid-naive patients with nociceptive pain intensity assessed by VAS (visual analogue scale) > 40 received controlled-release DHC as the first (15 patients, 7 days) or as the second opioid (15 patients, 7 days). Blood samples were tak...

The transmembrane water movements during cellular processes and their relationship to ionic channel activity remain largely unknown. As an example, in epithelial cells it was proposed that the movement of water could be directly linked to cystic fibrosis transmembrane conductance regulator (CFTR) protein activity through a cAMP-stimulated aqueous pore, or be dependent on aquaporin. Here, we use...

A coherence-controlled holographic microscope (CCHM) was developed particularly for quantitative phase imaging and measurement of live cell dynamics, which is the proper subject of digital holographic microscopy (DHM). CCHM in low-coherence mode extends DHM in the study of living cells. However, this advantage is compensated by sensitivity of the system to easily become misaligned, which is a s...

Abstract Manufacturing companies are facing new kinds of challenges. High cost and time pressure as well the variety product variants have added to supply chain issues due unvorseeable major political, societal or natural events. This requires more than ever load optimization for all agents a socio-technical system, enable them operate competitively sustainably. Digital tools offer possibility ...

The filtering of a digital situation model (DSM) containing points located on vegetation and buildings to a digital height model (DHM) is depending upon the structure of the objects not belonging to the bare ground. The limitation of an automatic global filtering of a DSM as a compromise between the different object classes is shown. Based on an automatic segmentation for each different class t...

Impaired epithelial wound healing has significant pathophysiological implications in several conditions including gastrointestinal ulcers, anastomotic leakage and venous or diabetic skin ulcers. Promising drug candidates for accelerating wound closure are commonly evaluated in in vitro wound assays. However, staining procedures and discontinuous monitoring are major drawbacks hampering accurate...

Cyclical stepping (gait) has been studied extensively. Some of these results are reflected in the straight and curved path step-following algorithms in commercial digital human modeling (DHM) implementations. With the aid of these algorithms, DHM users define start, intermediate, and end path points and the software generates a walking-like motion along the path. Most of these algorithms have s...