نتایج جستجو برای: dgat2 mogat2

تعداد نتایج: 161  

2014
Sonia J. Moisá Daniel W. Shike Dan B. Faulkner William T. Meteer Duane Keisler Juan J. Loor

Adipogenic/lipogenic transcriptional networks regulating intramuscular fat deposition (IMF) in response to weaning age and dietary starch level were studied. The longissimus muscle (LM) of beef steers on an early weaning (141 days age) plus high-starch diet (EWS) or a normal weaning (NW, 222 days age) plus starch creep-feed diet (CFS) was biopsied at 0 (EW), 25, 50, 96 (NW), 167, and 222 (pre-s...

ژورنال: علوم دامی ایران 2018
امیر رشیدی, امین مرتضوی محمد رزم کبیر, مصطفی قادری-‌زفره‌ئی پرهام مرادی,

هدف از این پژوهش، شناسایی ژن‌ها و کاوشگرهای هاب ناشی از ایجاد شبکه‌های بیزی در داده­های بیان ژن  و کاوشگری در بافت‌های مختلف گونۀ گاو با استفاده از داده‌های ریزآرایۀ DNA بود. با استفاده از داده­های خام بیان ژن و کاوشگری در هر بافت، ژن‌ها و کاوشگرهایی که عامل بیشترین میزان واریانس بیان ژن بودند، شناسایی‌شده و سپس شبکۀ بیزی، برای آن‌ها برازش داده شد. ژن­ها و کاوشگرهای هاب با استفاده از نسبت فراسن...

2014
Silvia M. A. Pedroni Sophie Turban Tiina Kipari Donald R. Dunbar Kerry McInnes Philippa T. K. Saunders Nicholas M. Morton Jane E. Norman

Maternal obesity is linked with increased adverse pregnancy outcomes for both mother and child. The metabolic impact of excessive fat within the context of pregnancy is not fully understood. We used a mouse model of high fat (HF) feeding to induce maternal obesity to identify adipose tissue-mediated mechanisms driving metabolic dysfunction in pregnant and non-pregnant obese mice. As expected, c...

2013
Zhenying Peng Lan Li Lianqun Yang Bin Zhang Gao Chen Yuping Bi

Diacylglycerol acyltransferase (DGAT) is the rate-limiting enzyme in triacylglycerol biosynthesis in eukaryotic organisms. Triacylglycerols are important energy-storage oils in plants such as peanuts, soybeans and rape. In this study, Arachis hypogaea type 2 DGAT (AhDGAT2) genes were cloned from the peanut cultivar 'Luhua 14' using a homologous gene sequence method and rapid amplification of cD...

Journal: :American journal of physiology. Endocrinology and metabolism 2008
Xing Xian Yu Susan F Murray Lynnetta Watts Sheri L Booten Justin Tokorcheck Brett P Monia Sanjay Bhanot

To investigate the role of JNK1 in metabolism, male ob/ob and diet-induced obese mice were treated with a JNK1-specific antisense oligonucleotide (ASO) or control ASO at 25 mg/kg or saline twice/wk for 6 and 7 wk, respectively. JNK1 ASO reduced JNK1 mRNA and activity by 65-95% in liver and fat tissues in both models. Compared with controls, treatment with JNK1 ASO did not change food intake but...

Journal: :Diabetes 2008
Victoria A. Payne Neil Grimsey Antoinette Tuthill Sam Virtue Sarah L. Gray Edoardo Dalla Nora Robert K. Semple Stephen O'Rahilly Justin J. Rochford

OBJECTIVE Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) is a recessive disorder featuring near complete absence of adipose tissue. Remarkably, although the causative gene, BSCL2, has been known for several years, its molecular function and its role in adipose tissue development have not been elucidated. Therefore, we examined whether BSCL2 is involved in the regulation of adipocyte ...

2017
Caroline Barisch Thierry Soldati

During a tuberculosis infection and inside lipid-laden foamy macrophages, fatty acids (FAs) and sterols are the major energy and carbon source for Mycobacterium tuberculosis. Mycobacteria can be found both inside a vacuole and the cytosol, but how this impacts their access to lipids is not well appreciated. Lipid droplets (LDs) store FAs in form of triacylglycerols (TAGs) and are energy reservo...

2016
Zeeshan Muhammad Iqbal Haji Akbar Afshin Hosseini Elena Bichi Ruspoli Forteguerri Johan S Osorio Juan J Loor

The hoof digital cushion is a complex structure composed of adipose tissue beneath the distal phalanx, i.e. axial, middle and abaxial fat pad. The major role of these fat depots is dampening compression of the corium underneath the cushion. The study aimed to determine expression of target genes and fatty acid profiles in the hoof of non-pregnant dry Holstein cows fed low (CON) or high-energy (...

2017
Sabrina J Nolan Julia D Romano Isabelle Coppens

Toxoplasma is an obligate intracellular parasite that replicates in mammalian cells within a parasitophorous vacuole (PV) that does not fuse with any host organelles. One mechanism developed by the parasite for nutrient acquisition is the attraction of host organelles to the PV. Here, we examined the exploitation of host lipid droplets (LD), ubiquitous fat storage organelles, by Toxoplasma. We ...

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