Poly(D,L-lactic-co-glycolic acid) (PLGA) microspheres were prepared by an oil/water emulsion solvent evaporation method to use as an injectable microcarrier for cell delivery. Three different kinds of PLGA microspheres having hydrophobic, negatively charged, and positively charged surfaces were prepared. Hydrophobic and negatively charged PLGA microspheres were prepared by using terminally capp...

Microspheres with high sphericity exhibit unique functionalities. In particular, their high symmetry makes them excellent omnidirectional optical resonators. As such perfect micrometre-sized spheres are known to be formed by surface tension, melt cooling is a popular method for fabricating microspheres. However, it is extremely difficult to produce crystalline microspheres using this method bec...

Background: Different methods have been used for BCG vaccination. Alginate microspheres are useful in delivery of vaccines to the gastrointestinal tract by oral route. Objective: To compare the immune response following oral microencapsulated and subcutaneous (SC) route administration of BCG vaccine in BALB/c mice. Methods: Alginate microspheres were produced by an internal emulsification metho...

In this study, the adsorption behavior of an alginate biopolymer microspheres containing D2 EHPA/TOPO (DTMCs) toward samarium (III) and gadolinium (III) ions was examined under various conditions. Scanning electron microscope (SEM) and thermogravimetric analysis (TGA) techniques were used to characterize the structure of microspheres. The average size of the microspheres was estimated around 50...

The control of size and size distribution of microspheres is necessary for obtaining repeatable controlled release behavior. The chitosan microspheres were prepared by a membrane emulsification technique in this study. Chitosan was dissolved in 1 wt.% aqueous acetic acid containing 0.9 wt.% sodium chloride, which was used as a water phase. A mixture of liquid paraffin and petroleum ether 7:5 (v...

conclusions: the results of the present study indicated that oral preparation of cm with an acceptable taste is feasible. background: chlorpheniramine maleate (cm) is widely used as an antihistaminic drug but it is very bitter and as yet no mouth dissolving/disintegrating taste-masked preparation that might be useful for pediatric and geriatric patients is available in the market. objectives: t...

The aim of this research was to investigate the effect non-invasive dermal electroporation (EP) on barrier function skin and permeation a model macromolecule in combination with different formulations. Skin samples were treated EP treatment for 2 min. Firstly, examined mouse vivo by measuring transepidermal water loss (TEWL). Then, human investigated ex under fluorescence microscope solution, h...

Microspheres formulated from poly (D, L-lactic-co-glycolide) (PLGA), a biodegradable polymer, have been extensively evaluated as a drug delivery system. In this study, the preparation, characterization and drug release properties of the PLGA microspheres were evaluated. Simvastatin (SIM)-loaded PLGA microspheres were prepared by oil-in-water emulsion/solvent evaporation method. The microspheres...

We have determined whether zein microspheres could act as vaccine adjuvants i.e. increase the immune responses to co-administered immunogens. Ovalbumin (model antigen)-loaded zein microspheres, blank zein microspheres and ovalbumin solution were intramuscularly administered to mice and the sera antibody levels were determined by ELISA. Another group of mice was orally dosed with blank zein micr...

The microsphere method has been used extensively to measure regional blood flow in large laboratory animals. A fundamental premise of the method is that microspheres do not alter regional flow or vascular tone. Whereas this assumption is accepted in large animals, it may not be valid in the pulmonary circulation of smaller animals. Three studies were performed to determine the hemodynamic effec...