Deuterium incorporation is crucial in organic synthesis and has wide applications the pharmaceutical industry. State-of-the-art H/D isotope exchange chemical defunctionalization for deuterium suffer from significant drawbacks, including expensive sources, low deuteration efficiency poor selectivity. In this perspective, we highlight an alternative pathway forming C-D bonds by electrocatalytic h...

Utilization of Photodisintegration reaction of Deuterium, 2H(?,n)1H, is a precise technique for determining the percentage of 2H in tritiated and natural water. The 23Na(n,?)24Na reaction is a suitable ?-source for producing the 2H(?,n)1H reaction. Tehran Research Reactor was used as a neutron source for producing 24Na isotopes. The BF3 detectors were used to detect the neutron emission of H2 c...

Deuterium labeling techniques are widely utilized as efficient tools to study the absorption, distribution, metabolism, and excretion (ADME) of pharmaceuticals. Moreover, deuterium-labeled drugs expected prolong half-life drug enhance efficacy drugs, close metabolic sites, decrease side effects. Thus, there is a rising demand for practical construction their intermediates under mild conditions....

A critical issue in determining whether or not the anomalous effects that occur during D2O electrolysis are of nuclear origin is the measurement of nuclear products in amounts sufficient to explain the rate of excess enthalpy generation. Calorimetric evidence of excess power up to 27% was measured during the electrolysis of heavy water using palladium cathodes. Maximum excess power was 0.52 W (...

Polycyclic aromatic hydrocarbons (PAHs) in water ice were exposed to ultraviolet (UV) radiation under astrophysical conditions, and the products were analyzed by infrared spectroscopy and mass spectrometry. Peripheral carbon atoms were oxidized, producing aromatic alcohols, ketones, and ethers, and reduced, producing partially hydrogenated aromatic hydrocarbons, molecules that account for the i...

OBJECTIVE To determine whether deuterium enrichment on carbons 5 and 3 (C5/C3) in plasma glucose is influenced by processes other than gluconeogenesis and, if so, whether these processes are altered by type 2 diabetes. RESEARCH DESIGN AND METHODS In this study, 10 obese diabetic and 10 obese nondiabetic subjects were infused intravenously with [3,5-(2)H(2)] galactose enriched at a C5-to-C3 ra...

The mean deltaD value of petiole water of Pterocarpus indicus Willd (deltaD = -9.0 +/- 2.5 per thousand, n = 3) was not significantly different from the mean value of stem water (-8.3 +/- 2.8 per thousand, n = 3). deltaD values of main vein water ranged from -11.1 to + 12.0 per thousand (n = 14) and increased along the main vein from petiole to the tip of leaves. Mesophyll water was highly enri...

We report a new method to measure the fraction of glucose derived from gluconeogenesis using gas chromatography-mass spectrometry and positive chemical ionization. After ingestion of deuterium oxide by subjects, glucose derived from gluconeogenesis is labeled with deuterium. Our calculations of gluconeogenesis are based on measurements of the average enrichment of deuterium on carbon 1, 3, 4, 5...

Changes in gravitational load have been shown to alter renal function, which could potentially affect water balance. Therefore, the present study was conducted to determine the effects of chronic centrifugation on water balance. Eight Sprague-Dawley rats were centrifuged (12 days at 2 G), and eight rats were used as a control group. Water balance over the course of the study was determined by q...