background: septins are an evolutionary conserved group of gtp-binding and filament-forming proteins that have diverse cellular roles. an increasing body of data implicates the septin family in the pathogenesis of diverse states including cancers, neurodegeneration, and male infertility. objective: the objective of the study was to evaluate the expression pattern of septin14 in testis tissue of...

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multiple sclerosis (ms) is an inflammatory, multifocal, immune-mediated disease of the central nervous system that women are at a higher risk to acquire than men. myxovirus resistance protein a (mxa) is used as a predictive marker of bioactivity of interferon-beta (ifn-β) therapy in ms patients. this study was undertaken in west of iran to investigate gender differences in the expression level ...

conclusions our findings showed that hcv infection could lead to increased expression level of tlr7 mrna in peripheral blood cells of hcv infected samples. the viral load and genotypes of hcv did not affect the mrna expression levels of tlr2 and tlr7. background hepatitis c virus (hcv) is an important human pathogen affecting an estimated 120 – 170 million individuals in the world. toll-like re...

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protein a is a commercially important protein in biotechnological and medicinal applications. the great value of this protein and its applications in genetic and protein engineering and microbial researches as well as the growing use in biochemical industries, biotechnology, medicine and pharmacology, highlight the importance of the present study. in this survey the encoding genes of full-lengt...

background: sporadic alzheimer’s disease (sad) is caused by genetic risk factors, aging and oxidative stresses. the herbal extract of rosa canina (r. canina), tanacetum vulgare (t. vulgare) and urtica dioica (u. dioica) has a beneficial role in aging, as an anti-inflammatory and anti-oxidative agent. in this study, the neuroprotective effects of this herbal extract in the rat model of sad was i...

background: cd19 is a pan b cell marker that is recognized as an attractive target for antibody-based therapy of b-cell disorders including autoimmune disease and hematological malignancies. the object of this study was to stably express the human cd19 antigen in the murine nih-3t3 cell line aimed to be used as an immunogen in our future study. methods: total rna was extracted from raji cells i...

background: rotaviruses cause diarrhea in infants and young children worldwide. rotavirus outer capsid protein, vp7 is major neutralizing antigen that is important component of subunit vaccine to prevent rotavirus infection. many efforts have been done to produce recombinant vp7 that maintain native characteristics. we used baculovirus expression system to produce rotavirus vp7 protein and to s...

background: ferroportin (fpn), a regulator of iron homeostasis is a conserved membrane protein that exports iron across the enterocytes, macrophages and hepatocytes into the blood circulation. fpn has also critical influence on survival of microorganisms whose growth is dependent upon iron, thus preparation of fpn is needed to study the role of iron in immunity and pathogenesis of micoorganisms...