This study was designed to confirm the previously observed favorable survival rates and prognostic factors in young children with nonmetastatic medulloblastoma (MB) treated with postoperative chemotherapy alone. Patients who received a diagnosis during the period January 2001 through December 2005 and who were aged <4 years received 3 cycles of postoperative systemic multiagent chemotherapy and...

BACKGROUND The tumour stroma is an important modulator of cancer cell behaviour. The aim of this study was to compare the stromal composition between primary colorectal cancer (CRC) and colorectal liver metastases (CLM). MATERIALS AND METHODS The stromal composition in matched tissue sections of CRC and subsequent CLM was analysed, and related to clinical parameters. RESULTS Differences in ...

Desmoplastic ameloblastoma is a relatively rare subtype of ameloblastoma. Tumor resection with curettage is considered the most reliable treatment for desmoplasticameloblastoma because of its aggressive behavior with bone invasion. A 43-year-old Japanese man presented with a swelling on the left side of his anterior maxilla. A painless, bone-like hard swelling was observed in the anterior maxil...

Desmoplastic gangliogliomas are rare mixed glial and neuronal cerebral tumors, especially described in infants below 4 years of age but exceptional cases have been reported in young adults. These tumors are generally localised in parietal or temporal lobes, present as a large cystic lesion with peripheral contrast enhancement. They also have characteristic histological features: extensive desmo...

UNLABELLED Desmoplastic fibroblastoma is benign soft tissue tumor, with fibroblastic or myofibroblastic origin, that rarely occurs in oral cavity. We reported the case of a 56-year-old man who presented a tumor in the left mandibular alveolar ridge, with slow and asymptomatic growth, with no osseous involvement. The tumor was sessile with lobulated surface, covered by healthy mucosa with erythe...

PURPOSE We aimed to test the hypothesis that medulloblastoma (MB) variants show a different age distribution and clinical behavior reflecting their specific biology, and that MB occurring at very young age is associated with cancer predisposition syndromes such as Gorlin syndrome (GS). EXPERIMENTAL DESIGN We investigated the frequency, age distribution, location, response to treatment, outcom...