Regular blood transfusions are essential support therapy for patients with transfusion-dependent anemias such as thalassemia and sickle cell disease. However, since humans lack a mechanism for the active excretion of excess iron, these patients invariably develop iron overload acquired from chronic blood transfusions. Since each milliliter of packed red blood cells (RBCs) processed for transfus...

INTRODUCTION The accumulation of amyloid-β is a pathological hallmark of Alzheimer's disease and is a target for molecular imaging probes to aid in diagnosis and disease monitoring. This study evaluated the feasibility of using a radiolabeled monoclonal anti-amyloid-β antibody (JRF/AβN/25) to non-invasively assess amyloid-β burden in aged transgenic mice (APPPS1-21) with μPET imaging. METHODS...

Diabetes mellitus (DM) is a serious and growing worldwide health problem and is associated with severe acute and chronic complications that negatively influence both quality of life and survival of affected individuals. It is a heterogeneous deregulation of carbohydrate metabolism. The liver is a central regulator of carbohydrate homeostasis and releases glucose according to metabolic demands. ...

Using light and electron microscopy, we investigated the in vivo distribution of liposomes Sterically stabilized by specific lipids which prolong their circulation in blood. Tissue distribution of sterically stabilized liposomes composed of distearoyl phosphatidylcholine: cholesterol:monosialoganglioside GMI (10:5:l)-encapsulated 67Ga-Desferal indicates that more than 30% of liposomes still rem...

BACKGROUND Photoimmunodetection, in which monoclonal antibodies [mAbs] are labeled with fluorescent dyes, might have clinical potential for early detection and characterization of cancer. For this purpose, the dye should be coupled in an inert way to mAb. In this study, different equivalents of IRDye800CW, a near-infrared fluorescent dye, were coupled to 89Zr-labeled cetuximab and bevacizumab, ...

Using light and electron microscopy, we investigated the in vivo distribution of liposomes sterically stabilized by specific lipids which prolong their circulation in blood. Tissue distribution of sterically stabilized liposomes composed of distearoyl phosphatidylcholine:cholesterol:monosialoganglioside GM1 (10:5:1)-encapsulated 67Ga-Desferal indicates that more than 30% of liposomes still rema...

D ear Editor, This letter responds to the commentary on our paper. We would like to thank Dr Alessandro Francesco Gualtieri for his interest in our paper and for his many constructive comments. We agree with the idea that asbestos-induced carcinogenesis requires a multidisciplinary perspective, including biochemistry, mineralogy, physics and toxicology, as he described. As pathologists, we reco...

Iron is an essential nutrient for almost all living cells, and pathogenic bacteria are faced with severe iron limitation in the mammalian host (1). To make iron available during infection, most microorganisms produce and transport into the cell specific iron chelators (siderophores) or acquire iron bound to exogenous iron carriers, like xenosiderophores, heme, or the host’s transferrins (2). Du...

To the Editor: Improvements in managing b-thalassaemia major have allowed many patients to survive beyond puberty. Fertility can, however, be impaired as a result of iron overload-related hypogonadism (1), although assisted reproductive techniques and advances in treating iron overload have increased the number of successful pregnancies in such patients (2–9). During pregnancy, patients may req...