objective: micrornas (mirnas) are noncoding rnas that function as key regulators of diverse biological activities such as cellular metabolism, cell proliferation and cell cycle regulation. recent studies have indicated the high potential of these small molecules to control stem cell differentiation into desired cells. the aim of present study is to investigate the possible effect of let-7f on e...

background: osteoarthritis is one of the most common diseases in middle‑aged populations in the world and could become the fourth principal cause of disability by the year 2020. one of the critical properties for cartilage tissue engineering (te) is the ability of scaffolds to closely mimic the extracellular matrix and bond to the host tissue. therefore, te has been presented as a technique to ...

Many hematopoietic growth factors are produced locally in the brain. Erythropoietin (EPO) is the principal growth factor regulating the production of red blood cells. Erythropoietin (EPO) isa glycoprotein hormone that acts as major regulator of erythropoiesis.Erythropoietin (EPO) has a dominant role for neuroprotection, neurogenesis and acting as neurotropic factor in the central nervous system...

BACKGROUND In studies on the possible role of viruses in the aetiopathogenesis of Alzheimer's disease, herpes simplex virus type 1 (HSV1) DNA was detected by the polymerase chain reaction (PCR) in a high proportion of normal elderly people and of patients with Alzheimer's disease. The combination of HSV1 and a host factor, the type 4 allele of the gene for apolipoprotein E, is a strong risk fac...

Dengue viral infection is on the rise in tropical urban and semi-urban parts of the world. WHO fact sheetN°117 updated in May 2015 estimates 390 million dengue infections per year and that 3900 million people, in 128 countries, are at risk. The WHO case definition of severe dengue includes organ impairment, but does not describe neurological manifestations as a separate entity. Earliest reports...

the compressibility factor of nonassociated chain molecules composed of hard convex core yukawa segments was derived with saft-vr and an extension of the barker-henderson perturbation theory for convex bodies. the temperature-dependent chain and dispersion compressibility factors were derived using the yukawa potential. the effects of temperature, packing fraction, and segment number on the com...

The review presents the results of studies on pharmacokinetics, metabolism, and bioavailability new neurotropic dipeptide cyclo-Lprolilglycine (CPG) their pharmacological activity. It was shown that pharmacologically active metabolite nootropic drug noopept is an endogenous dipeptide, it a fragment terminal Tripeptide insulin-like nerve growth factor IGF-1. Much attention paid both in Russia ab...