The concentration of iodine species can be measured using several different analysis methods. One of the most wellknown methods involves iodine titration with a thiosulfate solution. Total iodine can be analyzed using spectrometry, such as inductively coupled plasma-atomic emission spectrometry (ICP-AES), atomic absorption spectrometry (AAS) and inductively coupled plasma-mass spectrometry (ICP...

Meloxicam (MEL) (4-hydroxy-2-methyl-N-(5-methyl-2-thiazoly)-2H1,2-benzo-thiazine-3-carboxamide-1,1dioxide) (C14H13N3O4S2) (Figure 1) is a non-steroidal anti-inflammatory drug (NSAID) 1,2. MEL is a novel NSAIDs with a favorable COX-2 (cyclooxgenase-2): COX-1 (cyclooxgenase-1) selectivity has also been shown to have potent anti-inflammatory effects 3,4. Because of very low solubility of MEL in ac...

Determination of ascorbic acid (AA) in garlic, green pepper and chestnut was performed by derivative spectrophotometry without using any pre-separation or background correction techniques. The method is based on the measurement of the distances between two extremum values (peak-to-peak amplitudes) in second and third order derivative spectra of the extracts. Ten percent trichloroacetic acid was...

The absorbance and first-, second- and third-order derivative UV spectroscopic methods were applied for the determination of benazepril hydrochloride (BEN) in model solutions and tablets, as well as the estimation of its stability in solid phase. Derivative UV spectroscopy and HPLC methods were tested for: precision, linearity, accuracy and repeatability. HPLC was used as a reference method. Th...

Simple and sensitive methods using high-performance liquid chromatography-diode array detection (HPLC-DAD) and ultraviolet (UV)-spectrophotometry were developed and compared to quantify lychnopholide (LYC) in poly-ε-caprolactone nanocapsules and to study its release kinetics. Both methods were validated concerning their specificity, linearity, limits of detection and quantification, precision, ...

clonidine hydrochloride is an antihypertensive agent used for migraine prophylaxis, attention deficit hyperactivity disorder, menopausal flushing and tourette syndrome. the quantity of the active substance in pharmaceutical preparations must be within specific limits, in agreement with the respective label claim. therefore, the aim of this study was to establish the conditions for two spectroph...

extraction of trace amounts of toxic heavy metals from complicated environmental matrixes is a  challenging task. the aim of this investigation is the comparison of the extraction efficiencies and other related experimental variables ( chemicals, effect of ph, potential interfering ions) on the determination of inorganic lead ( ) which is present in waste water of dye industries. compared techn...

Three sensitive methods were developed for simultaneous determination of Ezetimibe (EZB) and Atorvastatin calcium (ATVC) in binary mixtures. First derivative (D(1)) spectrophotometry was employed for simultaneous determination of EZB (223.8 nm) and ATVC (233.0 nm) with a mean percentage recovery of 100.23 ± 1.62 and 99.58 ± 0.84, respectively. Linearity ranges were 10.00-30.00 μg mL(-1) and 10....