detoxification of children who are born from substance dependent mothers or those who are substance dependent themselves as a result of being abused by their families is a major concern. this report describes withdrawal symptoms and the way of abstinence in a 2.5 year-old girl who was dependent to opium. âfter that she was given opium for nearly two years suppress withdrawal symptoms, methadone...

in the following work we present a proof for the strong law of large numbers for pairwise negatively dependent random variables which relaxes the usual assumption of pairwise independence. let be a double sequence of pairwise negatively dependent random variables. if for all non-negative real numbers t and , for 1 < p < 2, then we prove that (1). in addition, it also converges to 0 in . the res...

background: to seek pleasure is man’s innate nature. in his search for gratification, man has discovered a world of substances that intoxicated him. those who fell within its trap, their life changed, their families aggrieved and they shrank from company. the addiction remained alone in the end. to many death was a relief. methods: a community based cross-sectional study was conducted in the ca...

periodontal ligament is a thin layer of soft tissue that connects root of a tooth to the surrounding alveolar bone. these ligaments play an important role in initiating tooth movement when loads are applied to teeth with orthodontic appliances. the majority of such soft tissues exhibit as viscoelastic bodies or have a time-dependent behavior. due to the viscoelastic behavior of the periodontal ...

introduction: the aim of this study was to assess the effect of ca2+/calmodulin-dependent kinase iiα (camkiiα) inhibitor (kn-93) injection into the locus coeruleus (lc) on the modulation of withdrawal signs. we also sought to study the effect of chronic morphine administration on camkiiα activity in the rat lc. methods: the research was based on behavioral and molecular studies. in the behavior...

introduction: activity of the paragigantocellularis (pgi) nucleus located in the rostral ventrolateral medulla is the mediator of dependence, tolerance and withdrawal syndrome. the most important systems which change their activity during morphine consumption include glutaminergic, opioidergicand purinergic (especially adenosine) receptors in the pgi nucleus. however, it has been shown that the...

In this study, the effect of reversible inactivation of locus ceruleus (LC) on naloxone- induced withdrawal syndrome in paragigantocellular (PGi) neurons in morphine- dependent rats was investigated. For inactivation of LC, 1 µl of lidocaine (2%) was used and for induction of withdrawal syndrome, naloxone hydrochloride (2 mg/kg) was injected systemically. The results showed that in dependent gr...

In this study the effect of adenosine and caffeine on spontaneous activity of paragigantocellularis (PGi) neurons was investigated. The spontaneous activity of PGi neurons was significantly decreased by microinjection of adenosine (10 nM, 0.5 µl) into PGi nucleus of both control and morphine-dependent rats. The decrease in firing rate of PGi neurons of morphine-dependent rats was greater than t...

conclusions the results showed that endurance training reduced pain by increasing apelin in morphine-dependent rats. therefore, it is suggested that this type of training be considered for the morphine-dependent patients for pain relief. objectives therefore, the aim of this study was to evaluate apelin and pain threshold changes in healthy and morphine-dependent rats in response to two exercis...

in the present study, the nonlinear model of non-newtonian blood flow in cosine-shape stenosed elastic artery is numerically examined. the model is carried out for axisymmetric, two-dimensional and fully developed blood flow. the vessel wall is assumed to be have time-dependent radius that is important factor for study of blood flow. the cosine-shape stenosis convert to rigid artery by using a ...