Florian Bossard,* Amal Robay,* Gilles Toumaniantz, Shehrazade Dahimene, Frédéric Becq, Jean Merot, and Chantal Gauthier Institut National de la Santé et de la Recherche Médicale Unité 533, l’ Institut du Thorax, Faculté de Médecine, Nantes; Centre National de la Recherche Scientifique Unité Mixte de Recherches 6187, Institut de Physiologie et Biologie Cellulaires, Université de Poitiers, Poitie...

This paper is an attempt to prove the following result:Let $n>1$ be an integer and let $mathcal{R}$ be a $n!$-torsion-free ring with the identity element. Suppose that $d, delta, varepsilon$ are additive mappings satisfyingbegin{equation}d(x^n) = sum^{n}_{j=1}x^{n-j}d(x)x^{j-1}+sum^{n-1}_{j=1}sum^{j}_{i=1}x^{n-1-j}Big(delta(x)x^{j-i}varepsilon(x)+varepsilon(x)x^{j-i}delta(x)Big)x^{i-1}quadend{e...

To evaluate the effect of Kaftrio on units lipase/kg/day, faecal elastase level, HbA1c, insulin doses (primary outcome measures) and weight (secondary measure) after a 6 month period in adult patients with cystic fibrosis (CF). Data was collected for under St Barts CF service that had started Kaftrio, at baseline months compared using paired t-test (p < 0.05). Patients were excluded where confo...

Overview: This document describes capabilities available through the CFTR Folding Consortium (CFC) and other groups pursuing F508 corrector screens and drug characterization. Included are specific areas of CFC investigator expertise, brief summaries of selected assays relevant to corrector mechanism of action, and new CFC protocols suitable for compound library screening. Academic and commercia...