background: sustained release delivery system can reduce the dosage frequency and maintain the therapeutic level of drugs for a longer time. biodegradable, biocompatible and thermosensitive chitosan-beta-glycerophosphate (c-gp) solutions can solidify at body temperature and maintain their physical integrity for a longer duration. objectives: to develop a novel delivery system based on the integ...

a topical preparation containing aceclofenac was developed using an o/w microemulsion system. isopropyl myristate was chosen as the oil phase as it showed a good solubilising capacity. pseudo-ternary phase diagrams were used to obtain the concentration ranges of the oil, surfactant (labrasol) and co-surfactant (plurol oleique) for microemulsion formation. five different formulations were formul...

nanoparticles have been at the center of research focus as a new promising material for the treatment of cancer in recent years. although many chemotherapy drugs for cancer treatment are available, their potential toxicity is the main point of concern. on the other hand, the conventional chemotherapeutic approach has not been found to be very efficient in colorectal cancer (crc) as the drug mol...

the aim of this investigation was to design and develop nanoemulsions (nes) as novel ophthalmic delivery systems for brinzolamide (bzd). phase behavior of quaternary systems composed of triacetin and capryoltm 90 (selected oils, screened through the solubility studies), various surfactants (namely, cremophor rh 40, brij 35, labrasol and tyloxapol), transcutol p (as co-surfactant) and water a...

objective(s): researchers have intended to reformulate drugs so that they may be more safely used in human body. polymer science and nanotechnology have great roles in this field. the aim of this paper is to introduce an efficient drug delivery vehicle which can perform both targeted and controlled antibiotic release using magnetic nanoparticles grafted ph-responsive polymer.  methods: fe3o4 na...

in this paper we address the vrpcd, in which a set of homogeneous vehicles are used to transport products from the suppliers to customers via a cross-dock. the products can be consolidated at the cross-dock but cannot be stored for very long as the cross-dock does not have long-term inventory-holding capabilities. the objective of the vrpcd is to minimize the total traveled distance while respe...

since its original conception in 1959, by nobel physicist richard p feynman, the notion of nanotechnology and its potential ramifications have not only created fascination,but also intense scientific efforts and scrutiny. one of the most promising applications of nanotechnology is in the context of medicine. due to their unique size-dependent properties nanomaterials such as nanoparticles offer...

absence of the sternum or asterniais the rarest developmental anomaly of the stern um. a female newborn is presented with asternia and asd.

background topical anesthesia is a safe and cost-effective method considered as the first-choice in many procedures. due to the physiological characteristics of eye, most of the local anesthetics cannot efficiently penetrate through the conjunctiva deep to tenon. the aim of this pilot study was to find a new form of lidocaine to give a sufficient level of anesthesia. methods: lidocaine cyclodex...

background: several multiphase flow analyses have been developed to predict the fate of particles used in inhalation drug delivery; however, the collapse of droplets during their passage through respiratory tract has not been investigated. objective: to assess the probability of droplet collapse in the upper respiratory tract. methods: a 3d model of mouth-to-second generation airway after the t...