Title Lercanidipine Rescues Hippocampus Pyramidal Neurons from Mild Ischemia-Induced Delayed Neuronal Death in SHRSP. Author(s) Sakurai-Yamashita, Yasuko; Harada, Noboru; Niwa, Masami Citation Cellular and molecular neurobiology, 31(4), pp.561-567; 2011 Issue Date 2011-05 URL http://hdl.handle.net/10069/24837 Right © Springer Science+Business Media, LLC 2011 NAOSITE: Nagasaki University's Acade...

Delayed neuronal cell death occurring hours after reperfusion is a hallmark of ischemic stroke and a primary target for neuroprotective strategies. In the present study, we investigated whether apoptosis-inducing factor (AIF), a caspase-independent proapoptotic protein, is responsible for neuronal cell death after glutamate toxicity and oxygen-glucose deprivation (OGD) in vitro and after experi...

The effects of intracerebroventricular administration of procaine 2 mumol on ischaemic release of neurotransmitter amino acids in the gerbil hippocampal CAI region were investigated using a microdialysis-high-performance liquid chromatography procedure. Histological outcome was examined by comparing delayed neuronal death between animals treated with procaine before ischaemia and animals treate...

Brain injury in newborns can cause deficits in motor and sensory function. In most models of neonatal brain injury, thalamic damage often occurs. Using the Rice-Vannucci model of neonatal hypoxic-ischemic brain injury, we have shown that neuronal degeneration in somatosensory thalamus is delayed in onset ( approximately 24 hr) compared with cortical and striatal injury and exhibits prominent st...

Xing, Hong, Aryan Azimi-Zonooz, C. William Shuttleworth, and John A. Connor. Caffeine releasable stores of Ca show depletion prior to the final steps in delayed CA1 neuronal death. J Neurophysiol 92: 2960–2967, 2004. First published June 16, 2004; 10.1152/ jn.00015.2004. In addition to their role in signaling, Ca ions in the endoplasmic reticulum also regulate important steps in protein process...

Objective(s): To reach an evidence-based knowledge in the context of the temporal-spatial pattern of neuronal death and find appropriate time of intervention in order to preserve spared neurons and promote regeneration after traumatic spinal cord injury (TSCI). Materials and Methods: The study design was based on Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA)-guided...

Programmed cell death occurs in the nervous and muscular system of newly emerged adult Drosophila melanogaster. Many of the abdominal muscles that were used for eclosion and wing-spreading behavior degenerate by 12 hr after eclosion. Related neurons in the ventral ganglion also die within the first 24 hr. Ligation experiments showed that the muscle breakdown is triggered by a signal from the an...