نتایج جستجو برای: deamidation
تعداد نتایج: 580 فیلتر نتایج به سال:
Cytotoxic necrotizing factors (CNFs) encompass a class of autotransporter toxins produced by uropathogenic E. coli (CNF1) or Y. pseudotuberculosis (CNFy). CNF toxins deamidate and thereby constitutively activate RhoA, Rac1, and Cdc42. In this study, the effects of CNF1 on cell-matrix adhesion are analysed using functional cell-adhesion assays. CNF1 strongly increased cell-matrix binding of susp...
The liberation of ammonia in the reaction of transferrin and ascorbic acid in phosphate buffer at pH 7.4, 37°C was investigated. It was found that transferrin is degraded in the reaction into smaller molecular weight polypeptides. The ammonia evolution was inhibited by catalase and by hydroxyl free radical trapping agents such as benzene, benzoate, and iodide. Dehydroascorbic acid and hydrogen ...
Posttranslational modification (PTM) of islet autoantigens can cause lack of central tolerance in type 1 diabetes (T1D). Tissue transglutaminase (tTG), involved in PTM of gluten antigens in celiac disease, creates negatively charged peptides favored by T1D-predisposing HLA-DQ molecules, offering an attractive candidate modifying islet autoantigens in T1D. The highly predisposing HLA-DQ8cis/tran...
Many bacterial toxins covalently modify components of eukaryotic signalling pathways in a highly specific manner, and can be used as powerful tools to decipher the function of their molecular target(s). The Pasteurella multocida toxin (PMT) mediates its cellular effects through the activation of members of three of the four heterotrimeric G-protein families, G(q), G(12) and G(i). PMT has been s...
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