DDT (bis[4-chlorophenyl]-1,1,1-trichloroethane) is a persistent insecticide that was used worldwide from the mid 1940s until its ban in the USA and other countries in the 1970s. When a global ban on DDT was proposed in 2001, several countries in sub-Saharan Africa claimed that DDT was still needed as a cheap and effective means for vector control. Although DDT is generally not toxic to human be...

Swi1 and Swi3 form the replication fork protection complex and play critical roles in proper activation of the replication checkpoint and stabilization of replication forks in the fission yeast Schizosaccharomyces pombe. However, the mechanisms by which the Swi1-Swi3 complex regulates these processes are not well understood. Here, we report functional analyses of the Swi1-Swi3 complex in fissio...

In vitro inhibition of Ca2+-ATPase by DDT homologs was studied using maternal brush-border membranes from human term placentas as an enzyme source. At 10 microM concentration many of the compounds tested inhibited this enzyme. The order of effectiveness of inhibition was as follows: p,p'-DDE greater than p,p'-DDD greater than p,p'-DDT greater than methoxychlor(mec). Both p,p'-DDOH and p,p'-DDA ...

DDT is a system for testing closed-source binary device drivers against undesired behaviors, like race conditions, memory errors, resource leaks, etc. One can metaphorically think of it as a pesticide against device driver bugs. DDT combines virtualization with a specialized form of symbolic execution to thoroughly exercise tested drivers; a set of modular dynamic checkers identify bug conditio...

Per the National Academy of Sciences: “To only a few chemicals does man owe as great a debt as to DDT.” That same committee concluded that in less than two decades of use, dichlorodiphenyltrichloroethane (DDT) had prevented 500 million deaths from malaria. So, what has been the history of DDT use by the U.S. military? How did a chemical with such an amazing ability to halt the spread of disease...

This paper studies the DeductionDetachment Theorem (DDT) in the realm of logics associated with bounded, commutative and integral residuated lattices whose consequence relation preserves degrees of truth (strictly speaking, it preserves the lower bounds of truth values of the premises). It is given some necessary conditions that must enjoy the varieties with a logic having the DDT. In two parti...

Remediation of pesticide-polluted soil is particularly challenging when pesticides in soil are aged and a mixture of pesticides is present. Application of zerovalent iron (Fe(0)) was investigated to accelerate the degradation of HCHs (alpha-, beta-, gamma- and delta-hexachlorocyclohexane) and DDX (DDT, DDE and DDD) in the soil from a former organochlorine pesticide manufacturing plant. Ultrason...

A study of the effect in rats of dichlorodiphenyl trichloroethane (DDT) on hepatocarcinogenesis that is initated by aflatoxin B1 (AFB1). In the first experiment, Buffalo rats were given a single oral dose of AFB1 (5 mg/kg) followed by dietary DDT (100 ppm) for 20 weeks. Neoplastic nodules were observed in 1 of the 14 AFB1-exposed rats, compared with 3 of the 19 rats in the AFB1/DDT group. In th...

Contact with the pesticide dichlorodiphenyltrichloroethane (p,p′-DDT) can be the cause of various harmful effects in humans, wildlife, and the environment. This pesticide is known to be persistent, lipophilic, resistant to degradation, and bioaccumulive in the environment and to be slowly released into bloodstream. Growing evidence shows that exposure to DDT is linked to type 2 diabetes mellitu...

OBJECTIVES To investigate the DDT and deltamethrin susceptibility of Phlebotomus argentipes, the vector of Leishmania donovani, responsible for visceral leishmaniasis (VL), in two countries (India and Nepal) with different histories of insecticide exposure. METHODS Standard WHO testing procedures were applied using 4% DDT and 0.05% deltamethrin impregnated papers. The effect of the physiologi...