AIM The present study was undertaken to estimate the current status of residues of organochlorine pesticides (OCPs), organophosphates (OPs) and synthetic pyrethroids (SPs) pesticides in human blood. MATERIALS AND METHODS Human blood samples were analyzed by gas chromatography and confirmed by gas chromatography-mass spectrometry in selective ion monitoring mode. RESULTS The gas chromatograp...

Lindhe, Ö. 2001. Adrenal Bioactivation and Toxicity of 3-MeSO2-DDE, o,p ́-DDD and DMBA Investigated in Tissue Slice Culture. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 675. 49 pp. Uppsala. ISBN 91-554-5185-3. I developed a precision-cut adrenal slice culture procedure to investigate cytochrome P450 (CYP) catalysed i...

Although concentrations of organochlorine compounds (OCs) in birds from most of the United States and Canada have decreased over the last 30 years, there is still concern that migrant birds might be exposed to elevated concentrations of OCs during migration in Latin America. The Lerma-Chapala Basin in west-central Mexico is an important migration corridor and wintering area for many species. Th...

BACKGROUND Premature labor is a poorly understood condition. Estrogen is thought to play a key role and therefore the labor process may be affected by endocrine disruptors. We sought to determine whether or not an environmental toxicant, DDE, or dietary derived endocrine disruptors, daidzein and genistein, are associated with spontaneous preterm labor. METHODS Cases were defined as primiparou...

Temporal and spatial trends in contaminant concentrations were assessed in Lake Erie watersnakes, a threatened (USA)/endangered (Canada) species restricted to western Lake Erie. Temporal changes in plasma contaminant levels were determined in 1990 and 2003, and spatial patterns in 2003 at 12 sites, throughout the species' range. During this period, the watersnakes' diet changed from fish (75%) ...

The carcinogenic potential of environmental xenoestrogens (i.e., organochlorines) is a matter of controversy. Their pathogenic role as promoters in breast cancer has been previously suggested. In Europe, despite their prohibition since the '70s, residues persist in soil and rivers resulting in a widespread contamination of the general population. In this study, we have compared the serum levels...

Persistent organochlorine pollutants (POPs) are ubiquitous, bioaccumulative compounds with potential endocrine-disrupting effects. They cross the placental barrier thereby resulting in in utero exposure of the developing fetus. The objective of this study was to investigate whether maternal serum concentrations of polychlorinated biphenyls (PCBs) and p,p'-dichlorodiphenyldichloroethylene (p,p'-...

The authors analyzed the relation between lactation history, organochlorine serum levels-in particular, 2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane (DDT) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE)-and the risk of breast cancer within a subsampe from a larger breast cancer case-control study conducted among women living in Mexico City, Mexico, between 1990 and 1995. From the origin...

This case-control study was designed to investigate the relationship between polychlorinated biphenyls (PCBs) and 1,1-dichloro-2,2*-bis(p-chlorophenyl)ethylene (DDE) and breast cancer risk in Connecticut. Cases were incident breast cancer patients who were either residents of Tolland County or who had a breast-related surgery at the Yale-New Haven Hospital in New Haven County. Controls were ran...