نتایج جستجو برای: dcm

تعداد نتایج: 3188  

2012
Stefan Brunner Andrei Todica Guido Böning Stefan G Nekolla Moritz Wildgruber Sebastian Lehner Martina Sauter Christopher Übleis Karin Klingel Paul Cumming Wolfgang Michael Franz Marcus Hacker

BACKGROUND We performed an initial evaluation of non-invasive ECG-gated [18 F]FDG-positron emission tomography (FDG-PET) for serial measurements of left ventricular volumes and function in murine models of dilated (DCM) and ischemic cardiomyopathy (ICM), and then tested the effect of erythropoietin (EPO) treatment on DCM mice in a preliminary FDG-PET therapy monitoring study. METHODS Mice dev...

Journal: :Molecular medicine reports 2015
Xin-Kai Qu Fang Yuan Ruo-Gu Li Lei Xu Wei-Feng Jing Hua Liu Ying-Jia Xu Min Zhang Xu Liu Wei-Yi Fang Yi-Qing Yang Xing-Biao Qiu

Dilated cardiomyopathy (DCM) is the most common form of primary myocardial disease. It is the most common cause of chronic congestive heart failure and the most frequent reason for heart transplantation in young adults. There is increasing evidence demonstrating that genetic defects are involved in the pathogenesis of idiopathic DCM. Recent studies have shown that genetically defective LRRC10 p...

Journal: :International journal of clinical and experimental medicine 2015
Fei F Chen Yun L Xia Cheng Q Xu Si S Li Yuan Y Zhao Xiao J Wang Shan S Chen Lian J Gao Yang Zhong Xin Tu Qing Wang Yan Z Yang

Two polymorphisms, rs7597774 and rs1739843 in ADD2 and HSPB7 respectively, were found to be associated with dilated cardiomyopathy (DCM) in European cohorts but the results were not validated in the Chinese Han population. We aimed to test the association of the two variants with DCM in a cohort of Chinese Han population. DCM (399) and control (1384) individuals were identified from the GeneID ...

Journal: :Clinical and vaccine immunology : CVI 2012
Robert Dennert Pieter van Paassen Petra Wolffs Catrien Bruggeman Sebastiaan Velthuis Susanne Felix Robert-Jan van Suylen Harry J Crijns Jan Willem Cohen Tervaert Stephane Heymans

Infections with cardiotrophic viruses and immune-mediated responses against the heart have been suggested to play a dominant role in the pathogenesis of idiopathic dilated cardiomyopathy (DCM). Furthermore, immune-mediated inflammatory diseases (IMIDs) may result in DCM. It has not previously been assessed whether DCM patients with and without an IMID have different prevalences and quantities o...

Journal: :International journal of clinical and experimental medicine 2015
Li-Jian Xie Ting-Ting Xiao Min Huang Jie Shen

OBJECTIVE To investigate whether LMNA gene mutation is associated with dilated cardiomyopathy (DCM) in Chinese Han Race children. METHODS DNA was isolated from 78 patients with DCM and 100 healthy Chinese children who served as controls. 12 exons in the functional regions and the adjacent part of introns of the LMNA gene were amplified with polymerase chain reactions (PCR) and the PCR product...

Journal: :civil engineering infrastructures journal 0
seyed bahram beheshti-aval associate professor, civil engineering faculty, k.n. toosi university of technology, tehran, iran ehsan jahanfekr ph.d. candidate, faculty of technical and engineering, hormozgan university, bandarabas, iran

displacement coefficient method (dcm) stipulated in the asce 41-06 standard is becoming the preferred method for seismic rehabilitation of buildings in many high-seismic-hazard countries. applications of the method for non-building constructions such as bridges are beyond the scope of this standard. thus its application to this kind of structure should be approached with care. target displaceme...

Journal: :JACC: Cardiovascular Imaging 2016

Journal: :American journal of physiology. Cell physiology 2007
Laura S Spruill Abigail S Lowry Robert E Stroud Christina E Squires Ira M Mains English C Flack Christy Beck John S Ikonomidis A Jackson Crumbley Paul J McDermott Francis G Spinale

Past studies have identified that a unique type of matrix metalloproteinase, the membrane-type-1 MMP (MT1-MMP), is increased within the left ventricle (LV) of patients with dilated cardiomyopathy (DCM). However, the cellular and molecular basis for this induction of MT1-MMP with DCM is unknown. LV myocardial biopsies from nonfailing, reference normal patients (defined as LV ejection fraction >5...

Journal: :The Tohoku journal of experimental medicine 1992
T Kanda T Yokoyama T Suzuki K Murata

We investigated abnormalities in natural killer (NK) cells in the myocardium and circulating blood of 38 patients with idiopathic dilated cardiomyopathy (DCM), 18 patients with hypertrophic cardiomyopathy, 8 patients with primary amyloidosis, and 12 age-matched normal control subjects. Immunohistochemical staining of myocardial biopsies revealed a significantly greater number of CD57-positive N...

2017
Ulrike Esslinger Sophie Garnier Agathe Korniat Carole Proust Georgios Kararigas Martina Müller-Nurasyid Jean-Philippe Empana Michael P. Morley Claire Perret Klaus Stark Alexander G. Bick Sanjay K. Prasad Jennifer Kriebel Jin Li Laurence Tiret Konstantin Strauch Declan P. O'Regan Kenneth B. Marguiles Jonathan G. Seidman Pierre Boutouyrie Patrick Lacolley Xavier Jouven Christian Hengstenberg Michel Komajda Hakon Hakonarson Richard Isnard Eloisa Arbustini Harald Grallert Stuart A. Cook Christine E. Seidman Vera Regitz-Zagrosek Thomas P. Cappola Philippe Charron François Cambien Eric Villard

AIMS Dilated cardiomyopathy (DCM) is an important cause of heart failure with a strong familial component. We performed an exome-wide array-based association study (EWAS) to assess the contribution of missense variants to sporadic DCM. METHODS AND RESULTS 116,855 single nucleotide variants (SNVs) were analyzed in 2796 DCM patients and 6877 control subjects from 6 populations of European ances...

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