Hypoxia in the tumor microenvironment is the leading factor in angiogenesis. Angiogenesis can be identified by dynamic contrast-enhanced breast MRI (DCE MRI). Here we investigate the relationship between perfusion parameters on DCE MRI and angiogenic and prognostic factors in patients with invasive ductal carcinoma (IDC). Perfusion parameters (Ktrans, kep and ve) of 81 IDC were obtained using h...

PURPOSE To compare pretreatment scans with perfusion computed tomography (pCT) vs. dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in rectal tumors. METHODS AND MATERIALS Nineteen patients diagnosed with rectal cancer were included in this prospective study. All patients underwent both pCT and DCE-MRI. Imaging was performed on a dedicated 40-slice CT-positron emission tomograph...

The aim of the study was to investigate the value of intravoxel incoherent motion diffusion-weighted magnetic resonance imaging (IVIM-DWI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in predicting the early and short-term responses to chemoradiotherapy (CRT) in patients with nasopharyngeal carcinoma (NPC).Forty-three NPC patients underwent IVIM-DWI and DCE-MRI at baseline...

PURPOSE To investigate the correlations between parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and prognostic factors in rectal cancer. MATERIALS AND METHODS We studied 29 patients with rectal cancer who underwent gadolinium contrast-enhanced, T1-weighted DCE-MRI with a three Tesla scanner prior to surgery. Signal intensity on DCE-MRI was independently measured b...

Using hypercapnia and carbogen as functional markers of vessel maturation and function, we compared blood oxygen level-dependent (BOLD) contrast with standard dynamic contrast-enhanced (DCE)-MRI quantitative parameters in murine fibrosarcoma. Our results show that there was no correlation between vessel maturity and contrast-agent uptake rate (K(in) (Trans)) or contrast agent efflux rate (k(ep)...

Abstract Background The purpose of this study was to investigate the diagnostic performance diffusion weight imaging (DWI), apparent coefficient (ADC) map, normalized ADC liver, and spleen compared dynamic contrast-enhanced MRI (DCE-MRI) in evaluation residual hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA) using 3 T (T) magnetic resonance (MRI). Results A prospective perform...

Introduction We have recently shown that quantitative pre-surgery dynamic contrast-enhanced (DCE) MRI can potentially be an important imaging biomarker for accurate prediction of therapeutic response and long-term survival of patients with osteosarcomas (1). However, patient discomfort and resulted motion are consistently problematic during a DCE-MRI study of 5 min or longer. Therefore, without...

Introduction Conventional mammography is known to have high false positive rate (60-80%) in detection of breast malignancy, resulting in unnecessary biopsies. Recently, dynamic contrast enhanced (DCE) MRI demonstrated high sensitivity (88-100%), but rather limited and variable specificity (37-97%) in diagnosis of breast cancer (1). In vivo H MRS showed excellent specificity in detection of mali...

Abstract Background Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has always been a problem solver in troublesome breast lesions. Despite its many advantages, the encountered low specificity results unnecessary biopsies. Diffusion-weighted MRI (DW-MRI) is well-established technique that helps characterizing lesions according to their water diffusivity. So this work aimed assess...

conclusion the possibility of malignancy is strongly indicated when additional nme lesions show linear or segmental enhancement on preoperative 3t dce-mri in patients with recently diagnosed breast cancer. results on histopathologic analysis of the 88 nme lesions, 73 (83%) were malignant and 15 (17%) were benign. lesion size did not differ significantly between malignant and benign lesions (p =...