PURPOSE The DNA methylation paradox, manifested as derepression of cancer-testis antigens, and silencing of tumor suppressors during malignant transformation, provides the rationale for the utilization of chromatin remodeling agents for cancer therapy. A phase I trial was done to examine pharmacokinetics, toxicities, and gene expression mediated by 5-aza-2'-deoxycytidine (DAC) in patients with ...

A 9-bit 11GS/s current-steering (CS) digital-to-analog converter (DAC) is designed in 28nm FDSOI. The DAC uses two-times interleaving to suppress the effects of the main error mechanisms of CS DACs while its clock timing can be tuned by the back gates bias voltage of the multiplexer transistors. The DAC achieves higher than 50dB SFDR and less than -50dBc IM3 over Nyquist at a sampling rate of 1...

h DAC CONTINUES TO play a unique role as an information sharing forum, where the wide range of its offerings allows DAC participants to learn, network and conduct business. In the past 50 years, DAC has been evolved from being an EDA conference to becoming more of a design ecosystem conference and extending into design methods, IP, foundries, design services, and Embedded Systems & Software (ES...

This study provides insights into the feasibility of a desiccant dehumidification-based Maisotsenko cycle evaporative cooling (M-DAC) system for greenhouse air-conditioning application. Conventional techniques include direct cooling, refrigeration systems, and passive/active ventilation. which are commonly used in Pakistan; however, they either not feasible due to their energy cost, or cannot e...

DAC is an important module within the SAR ADC, innovation design on DAC structure to ensure the accuracy of components is the key component to improve the performance of SAR ADC. Based on the comprehensive analysis on some kinds of DAC structures used in SAR ADC, the traditional structure of the resistance and capacitance structures was optimized and two innovative design methods were proposed ...

A digital calibration technique for high resolution SAR ADC with only one redundant conversion bit is presented in this paper. The proposed work employs no extra calibration DAC or input signal as calibration reference. Calibration signal is generated through switching redistribution DAC in two calibration phase, so that calibration accuracy will not be affected by input signal distribution. DA...

A dynamic element matching algorithm, data weighted averaging, is introduced for use in multi-bit data converters. Using this algorithm, distortion spectra from DAC linearity errors are shaped by rst-order noise shaping, resulting in a dynamic range improvement of 9 dB/octave when DAC errors dominate. Combining this technique with random dithering eliminates the aliasing of the DAC errors into ...

While Mandatory Access Controls (MAC) are appropriate for multilevel secure military applications, Discretionary Access Controls (DAC) are often perceived as meeting the security processing needs of industry and civilian government. This paper argues that reliance on DAC as the principal method of access control is unfounded and inappropriate for many commercial and civilian government organiza...

Due to great value of the time constant of the integrator circuit, a hardware defined PWM (Pulse Width Modulation) signal makes it possible to build a Digital to Analog Converter (DAC) characterized by a relatively long response time. An attempt at creating the software defined PWM signal leads to increased response time of the DAC converter with a coefficient several hundred times longer than ...