BACKGROUND Dopamine D(3) receptors are involved in the pathophysiology of several neuropsychiatric conditions. [(11)C]-(+)-PHNO is a radiolabeled D(2) and D(3) agonist, suitable for imaging the agonist binding sites (denoted D(2HIGH) and D(3)) of these receptors with positron emission tomography (PET). PET studies in nonhuman primates documented that, in vivo, [(11)C]-(+)-PHNO displays a relati...

The splanchnic bed produces cortisol at rates approximating extraadrenal tissues by converting cortisone to cortisol via the 11beta-hydroxysteroid dehydrogenase (11beta-HSD) type 1 pathway. It is not known whether splanchnic cortisol production is regulated by nutrient ingestion and/or by the accompanying changes in hormone secretion. To address this question, 18 healthy humans were randomized ...

A bstract We construct new families of $$ \mathcal{N} N = (0 , 4) AdS 3 × S 2 {\tilde{S}}^2 S ˜ 2 1 backgrounds fibred over a 2d Riemann surface in Type IIB string theory. These solutions are obtained by extract...

In this paper we consider the problem of finding a vector that can be written as a nonnegative, integer and linear combination of given 0-1 vectors, the generators, such that the l1-distance between this vector and a given target vector is minimized. We prove that this closest vector problem is NP-hard to approximate within an additive error of (ln 2− ǫ)d ≈ (0, 693 − ǫ) d for all ǫ > 0 where d ...

In this paper we consider the problem of finding a vector that can be written as a nonnegative, integer and linear combination of given 0-1 vectors, the generators, such that the l1-distance between this vector and a given target vector is minimized. We prove that this closest vector problem is NP-hard to approximate within an additive error of (ln 2− ǫ)d ≈ (0, 693 − ǫ) d for all ǫ > 0 where d ...

The production of 1,24,25-trihydroxyvitamin D3 in vivo in vitamin D-deficient rats has been demonstrated from either 25-hydroxyvitamin D3 or 1,25-dihydroxyvitamin D3. The stereochemical configuration of the hydroxyl on the 24 position of 1,24,25-trihydroxyvitamin D3 has also been unambiguously established to be R. Nephrectomy failed to eliminate the conversion of 1,25-dihydroxyvitamin D3 to the...

The expression of retinoblastoma (pRb) and cyclin D3 proteins is highly induced during the process of skeletal myoblast differentiation. We have previously shown that cyclin D3 is nearly totally associated with hypophosphorylated pRb in differentiated myotubes, whereas Rb-/- myocytes fail to accumulate the cyclin D3 protein despite normal induction of cyclin D3 mRNA. Here we report that pRb pro...

Cholate-solubilized chick kidney mitochondria that 1-hydroxylated 25-hydroxyvitamin-D3 (25-OH-D3) upon reconstitution also produced 10-oxo-19-nor-25-OH-D3, which co-eluted with 1,25-dihydroxyvitamin D3 (1,25-(OH)2-D3) on normal phase high performance liquid chromatography (HPLC) with hexane:propanol-2 (9:1), the traditional chromatographic system for isolating 1,25-(OH)2-D3. The 10-oxo derivati...

Abstract In this study, nutrients digestibility and growth performance of Nile tilapia ( Oreochromis niloticus ) fed on oilseed meals with crude papain enzyme were determined. A control diet (D1) 30% protein (CP) was formulated using fishmeal (FM), soybean meal (SBM), canola (CM) sunflower (SFM). The test diets replacing 10% CP FM by SBM (D2), CM (D3) SFM (D4), respectively. Crude in powder for...