Poly(7-glutamic a id) (PGA) production ill Bacillas suhtitis IF03335 was studied. When citric acid as a carbon source was added to a glutamic acid medium containing L-glutamic acid and ammonium sulfate, a large amount of pure PGA wEs produced. On the other hand, when glucose was added to the glutamic acid medium, a by-preduct was produced, which seemed to be a polysaccharide. Moreoyer, the mode...

The direct effects of glutamate and dizocilpine maleate (MK-801, non-competitive N-Methyl-D-aspartate glutamate receptor antagonist) on the metabolism of dopamine were investigated in the striatum of normal and parkinsonian rats. L-dopa, L-glutamic acid and MK-801 were administered in the striatum locally by microdialysis. 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were ...

The significance of mammalian D-amino acid oxidase (DAAO) has not been established. Little is known of the source of its substrates, since only the L form appears to be involved in the me tabolism of amino acids in higher animals. In vivo isotope dilution studies (22) have indicated that normal mammals contain no free D-tyrosine or D-glutamic acid, although Kögl (13) has re peatedly reported t...

1. The characteristics of transport and hydrolysis of twenty-two dipeptides containing basic and acidic amino acids by rat ileal rings were investigated in vitro. The peptides included combinations of basic and neutral, basic and basic, basic and acidic, acidic and acidic, and acidic and neutral amino acids. 2. All peptides studied were removed intact from the bulk phase of the incubation mediu...

Although glutamic acid is known to be a precursor for proline biosynthesis, the enzymatic conversion of glutamic acid to pyrroline-5-carboxylic acid, the immediate precursor of proline, has not been demonstrated in cell-free systems. By providing appropriate concentrations of ATP and NADPH and blocking further metabolism of pyrroline-5-carboxylic acid, we have developed a method for measuring t...

Abstract In this paper, we examined the competence of amino acids as standards for instrumental biochemical analysis. The chosen were first dissolved in various aquatic solutions and then measured a benchtop NMR spectrometer, which is not common choice such analytical investigations. Analysis by mass spectrometry was used addition. As part these investigations, determined stability ornithine, g...