The present study investigated the effects of co-administration of aspirin, metformin, atorvastatin and captopril on serum lipid profile and oxidative stress in the heart and kidney of streptozotocin-induced diabetic rats. In this study, rats were randomly divided into the following eleven groups: control (Cont.), and diabetic (D), as well as 9 groups that were treated with metformin (M, 300 mg...

I n the modern competitive world, Research and Development (R&D) and its overflowing technologies are the main basis of innovation, which in turn, can be determined as an important source of economic growth. Investing in research activities can help firms with different technological levels, especially high-tech industries to improve their productivity. This paper aims to analyze the...

Since the feasibility study of R&D programs have been initiated for efficient public R&D investments, year 2008, feasibility studies have improved in terms of precision. Although experience related to these studies of R&D programs have increased to a certain point, still methodological improvement is required. The feasibility studies of R&D programs are consisted of various viewpoints, such as ...

introduction: the process of wound healing sets in motion a complex and dynamic series of events, which includes the remodeling of the extracellular matrix degradation of matrix proteins, predominantly collagen fibers, mediated by matrix metalloproteinase (mmps). our aim was to demonstrate whether fibroblasts derived from various strains of human fetal foreskin (fs) and adult skin (as), when cu...

In this study, we aimed to determine VEGFR-2, EGFR and PDGFR-β tyrosine kinase inhibitory activities of some pyrrolo[2,3-d]pyrimidine derivatives previously synthesized and showed potent cytotoxic and apoptotic effects against several cancer cell lines by our group and to evaluate the relationships between inhibitory activities and binding properties of the active compounds by molecular docking...

This article presents a broad view of systems analysis and design (SA&D) research. Although SA&D is a critical area of research in the information systems field, relatively little such research has been published in leading IS journals. To point toward increased research opportunities for SA&D work, this article presents a framework that illustrates the broad range of activities within the SA&D...

This paper presents spatially arranged microelectrode probes to allow electrophysiological recordings inside 3–D neuronal cultures. Out–of–plane microelectrode probes standing on a substrate have gradation in height. Wire– bonding–based probe technology [1] makes it possible to provide the flexible probes. We would understand the dependent alteration of cellular activities caused by the constru...