background and objectives: cancer is a public health problem all over the world. herbal medicines have a vital role in the prevention and treatment of cancer and large numbers of plants and their isolated constituents have shown potential anticancer activity. methods: twenty seven medicinal plants from southern iran provinces have been extracted with methanol and screened for their cytotoxic ac...

objective(s):this study aims at exploring cytotoxic activity of different peptides derived from vsvg protein against mcf-7 and mda-mb-231 breast cancer cell lines and human embryonic kidney normal cell (hek 293).    materials and methods: the anticp web server was used to predict anticancer peptides. the cytotoxic activity of peptides with high score (p26, p7) and low score (p19) was examined b...

different acid chlorides (2a-d) reacted with anthranilic acid to produce 2-substituted-3, 1-benzoxazin-4-one (3a-d) which was used as starting material to synthesize some condensed and non-condensed heterocyclic compounds by reaction with nitrogen nucleophiles e.g., hydrazine hydrate, and formamide. some of the newly synthesized analogues were chosen to evaluate their cytotoxic activity against...

salvia is one of the largest genera of  lamiaceae family. several species of this genus are perfumed and wealthy in essential oils. some of them are used in industry, pharmacy and aromatherapy. they have shown different biological effects such as antibacterial and antioxidant activity. for the present study, salvia verticillata l. was collected from shahrestanak, mazandaran, iran. hydrodistille...

objective: homalium letestui pellegr (flacourtiaceae) is used in traditional medicine in parts of nigeria for the treatment of malaria, ulcer, and inflammatory diseases and as an aphrodisiac. this investigation was aimed to evaluate the cytotoxic, immunomodulatory, and antileishmanial properties of stem extract and fractions of homalium letestui (h. letestui). materials and methods: cytotoxic a...

background: achillea talagonica (asteraceae) is an endemic herbaceous plant in iran with small yellow flowers and several times pinnately divided leaves in worm shape. the plant was found to be cytotoxic in our previous studies.   materials and methods: a. talagonica was collected in may 2005 from talegan in north of iran during the full flowering stage. dried aerial parts of the plant were red...

Microorganisms are exposed to reactive oxygen species (ROS) that formed in various ways, particular, as a result of respiration or other intracellular processes, during metal-catalyzed Fenton reactions, the action UV- and X-radiation, under influence some antimicrobial drugs, host immune oxidative-burst response against infection agents. In this review, we take look at mechanisms microbial cell...

In vitro and in vivo-generated cytotoxic T lymphocytes (CTL) specific for major and minor histocompatibility antigens evoked antigen-specific full-thickness skin necrosis when injected intradermally into allogeneic mice in a variety of strain combinations. In addition, CTL-target-cell mixtures injected intradermally into hosts syngeneic to the CTL also evoked destruction of host tissue. These "...

Paraphenylenediamine (PPD) is a synthetic chemical widely used as substitute for henna permanent hair dye because it gives natural look to the and dyed can also be shampooed or permed without losing colour. However, intermediate partially oxidized form of PPD reported cause adverse reactions in people. Effects sublethal concentrations zebra fish were examined 15 days following exposure chemical...