In recent years, the use of combined first-trimester screening (CFTS) and cell-free DNA (cfDNA) has increased. With rise CFTS cfDNA prenatal testing, there been a dramatic decrease in number invasive diagnostic tests performed during pregnancy. this study, authors record-linkage study to obtain state-wide cfDNA, CFTS, postnatal cytogenetic data determine utilization performance different geneti...

background: the secondary genetic changes other than the promyelocytic leukemia-retinoic acid receptor (pml-rara) fusion gene may contribute to the acute promyelocytic leukemogenesis. chromosomal alterations and mutation of flt3 (fms-like tyrosine kinase 3) tyrosine kinase receptor are the frequent genetic alterations in acute myeloid leukemia. however, the prognostic significance of flt3 mutat...

Biological techniques such as Array-Comparative genomic hybridization (CGH), fluorescent in situ hybridization (FISH) and affymetrix single nucleotide pleomorphism (SNP) array have been used to detect cytogenetic aberrations. However, on genomic scale, these techniques are labor intensive and time consuming. Comparative genomic microarray analysis (CGMA) has been used to identify cytogenetic ch...

objective: the present retrospective study aims at identifying the prevalence of chromosomal abnormalities in a population of couples who are candidates for assisted reproductive techniques. materials and methods: cytogenetic analysis was performed according to the standard methods on cultured cells from the patients’ peripheral blood. the culture, was harvested after 72 hours. at least 20 meta...

total or partial absence or excess of the sex chromosomes produces different karyotypes and phenotypical abnormalities. upon retrospective analysis of the results of 163444 cytogenetic tests that were performed during 28 years (1987-2015) in this center, different types of sex chromosomal aberrations and the clinical phenotypes are delineated in this article. moreover, the clinical course and t...

OBJECTIVE Chromosomal aberrations are common causes of multiple anomaly syndromes. Recurrent chromosomal aberrations have been identified by conventional cytogenetic methods used widely as one of the most important clinical diagnostic techniques. MATERIALS AND METHODS In this retrospective study, the incidences of chromosomal aberrations were evaluated in a six year period from 2005 to 2011 i...

Aim. The main goal of this study was to the anti-radiation effect guaninium-zinc chloride complex on cytogenetic changes in irradiated rats. Methods. White rats Wistar line with an average weight 110-125 grams served as material for detection complex. Animals were injected intraperitoneally solutions at a concentration 40 mg/kg 2 hours before irradiation and subjected general uniform gamma from...

Early identification of fetuses with chromosomal abnormalities enables health care providers to form an appropriate management plan for each patient. The main objective of this study was to determine the role of ultrasonography in screening and identifying fetuses at risk for chromosomal abnormalities. A retrospective review of 6480 patients from the Obstetrics and Gynecology ward of Firou...