نتایج جستجو برای: cytochrome c oxidase
تعداد نتایج: 1117460 فیلتر نتایج به سال:
Cytochrome c oxidase catalyzes the reduction of oxygen to water. This process is accompanied by the vectorial transport of protons across the mitochondrial or bacterial membrane ("proton pumping"). The mechanism of proton pumping is still a matter of debate. Many proposed mechanisms require structural changes during the reaction cycle of cytochrome c oxidase. Therefore, the structure of the cyt...
Analysis of the rotational mobility of spin-labeled bovine heart cytochrome c oxidase by saturation transfer electron paramagnetic resonance(ST-EPR) has recently demonstrated that this enzymic complex can be obtained as an aggregate of individual protein molecules which display little or no rotational mobility on the submillisecond time scale (1). Aggregation appears to occur as a result of pro...
There is an increasing demand for the development of intermediate biomarkers to assess colon cancer risk. We previously determined that a live cell bioassay, which assesses apoptosis resistance in the nonneoplastic colonic mucosa, detects approximately 50% of patients with colon cancer. A hypothesis-driven biomarker that reflects apoptosis resistance in routine formalin-fixed, paraffin-embedded...
Identification of Intracellular Sources Responsible for Endogenous Reactive Oxygen Species Formation
The endogenous reactive oxygen species ("ROS") formation is associated with many pathologic states such as inflammatory diseases, neurodegenerative diseases, brain and heart ischemic injuries, cancer, and aging. The purpose of this study was to investigate the endogenous sources for "ROS" formation in intact isolated rat hepatocytes, in particular, peroxisomal oxidases, monoamine oxidase, xanth...
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