The title compound, C17H27O8P, was prepared by Michaelis-Arbuzov reaction of ethyl 2-bromo-2-(2,3,4-tri-meth-oxy-phen-yl)acetate and triethyl phosphite. Such compounds rarely crystallize, but single crystals were recovered after the initial oil was left for approximately 10 years. The bond angle of the sp (3)-hybridized C atom connecting the benzene derivative with the phospho unit is widened m...

Many metals or their complexes can catalyze the cyclotrimerization of alkynes to give benzene derivatives.1-9 Among these catalysts, palladium chloride10 and its bis(benzonitrile) complex11 are the most convenient. In these reactions, the yields of benzene derivatives generally depend on the substituents of alkynes. In the past 50 years, the regioand chemoselectivity for the cyclotrimerization ...

The current strategy for identifying the carcinogenicity of drugs involves the 2-year bioassay in male and female rats and mice. As this assay is cost-intensive and time-consuming there is a high interest in developing approaches for the screening and prioritization of drug candidates in preclinical safety evaluations. Predictive models based on toxicogenomics investigations after short-term ex...

The gestagenic and antiandrogenic drug cyproterone acetate (CPA) is mitogenic, tumorigenic and induces DNA-adducts and DNA-repair synthesis in rat liver. Thus CPA is expected to be mutagenic. However in vitro mutagenicity test systems were negative. To examine whether CPA induces mutations in rat liver, the in vivo mutation assay based on Big Blue transgenic F344 rats was employed. Single oral ...

The CPA wanted also to invite psychiatrists to pause and allow themselves a period of recollection on what they are in an era of changing conceptual, organizational, and philosophical issues on the shape of psychiatry—a revolutionary period driven by technological advance. By its nature, a period of revolution is a period of uncertainty. Added to the fact that our health system is experiencing ...

Sociologists have been struggling to concur on a single definition that can encapsulate the notion of a profession. This paper gives an overview of the definitional problem on the concept of profession and offers a further understanding of this concept by adopting a historical perspective. The accounting profession in China is chosen as a case study, and the process of professionalisation of th...

It is incumbent on organisations to find ways to support their employees and help them achieve their full potential; they must provide employees with conditions that promote psychological health. Based on a series of studies conducted by Dr. Claude Fernet, recipient of the 2012 CPA President’s New Researcher Award, this article sheds light on the role of work motivation in employees’ psychologi...

OBJECTIVE This paper examined the relationship between exposure to sexual and physical abuse (CSA and CPA) in childhood and later educational achievement outcomes in late adolescence and early adulthood in a birth cohort of over 1,000 children studied to age 25. METHOD Retrospective data on CSA and CPA were gathered at ages 18 and 21 and used to form a best estimate of exposure to CSA and CPA...