Mice challenged intranasally with Naegleria fowleri died of primary amoebic meningoencephalitis. Mice given 30 mg of cyclophosphamide per kg of body weight daily for 10 days starting 2 days before challenge were protected. Neither cyclophosphamide nor serum from cyclophosphamide-treated mice inhibited N. fowleri in vitro. A metabolic product of cyclophosphamide, acrolein, inhibited growth and e...

fusarium graminearum is causal agent of economically catastrophic disease of cereal fusarium head blight (fhb) around the world. in addition to causing a loss of yield, this fungus causes serious threats to humans and animals due to the contamination of grain with the trichothecene mycotoxin. tri101 gene, a fusarium spp. gene, encodes an enzyme that transfers an acetyl group to the c3 hydroxyl ...

background: one of the problems that addicts suffer from is decreased libido. erectile dysfunction has been reported in men using opioids for treatment of heroin addiction. objective: the study was performed to investigate the effects of morphine and detoxification with methadone as causes of sexual dysfunction in addiction. methods and methods: a total of 40 adult male rats (wistar) were used....

background: the common detoxification method is replacement of long effect opiate by short effect opiate and then reducing its amount gradually. more modern method is ultra rapid opiate detoxification (urod) by opiate antagonists, which is performed by general anesthesia. the advantages of two methods have not been confirmed. this study aimed to compare effectiveness and withdrawal rate in both...

INTRODUCTION Cyclophosphamide is commonly used as an important component in conditioning prior to hematopoietic stem cell transplantation, a curative treatment for several hematological diseases. Cyclophosphamide is a prodrug activated mainly by cytochrome P450 2B6 (CYP2B6) in the liver. A high degree of inter- and intra-individual variation in cyclophosphamide kinetics has been reported in sev...

BACKGROUND Many drug users present to primary care requesting detoxification from illicit opiates. There are a number of detoxification agents but no recommended drug of choice. The purpose of this study is to compare buprenorphine with dihydrocodeine for detoxification from illicit opiates in primary care. METHODS Open label randomised controlled trial in NHS Primary Care (General Practices)...

abstract background: chemotherapy- induced nausea and vomiting (cinv) occur frequently causing problems with an unacceptably high incidence that significantly affect patients' daily functioning and health-related quality of life. the present study was aimed to compare acute cinv for granisetron as 5-ht3 receptor antagonist and metoclopramide in the patients receiving chemotherapeutic regimens i...