نتایج جستجو برای: cyclopentanone

تعداد نتایج: 199  

Journal: :Nature chemical biology 2009
Sandra Fonseca Andrea Chini Mats Hamberg Bruce Adie Andrea Porzel Robert Kramell Otto Miersch Claus Wasternack Roberto Solano

Hormone-triggered activation of the jasmonate signaling pathway in Arabidopsis thaliana requires SCF(COI1)-mediated proteasome degradation of JAZ repressors. (-)-JA-L-Ile is the proposed bioactive hormone, and SCF(COI1) is its likely receptor. We found that the biological activity of (-)-JA-L-Ile is unexpectedly low compared to coronatine and the synthetic isomer (+)-JA-L-Ile, which suggests th...

Journal: :Medicinal Chemistry Research 2023

Abstract Alzheimer’s disease (AD) is a multifactorial incurable neurodegenerative disorder. To date, cholinesterase inhibitors (ChEI) are the mainstay line of treatment to ameliorate symptoms AD. Tacrine and donepezil considered two important cornerstones anti-dementia drugs. Accordingly, novel series hexahydrobenzothienocyclopentapyridines, octahydrobenzo-thienoquinolines, hexahydrocyclopenta(...

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