نتایج جستجو برای: cyclic act
تعداد نتایج: 276188 فیلتر نتایج به سال:
The cyclic model resolves the homogeneity and atness problems of big bang cosmology via a period of ultra-slow contraction rather than the accelerated expansion found in in ationary schemes. Patches of space in the four-dimensional e ective theory undergo repeated big bangs, thus allowing the introduction of timescales far greater than the 14 billion years since the last one. The conditions imp...
Cyclic nucleotide-gated channels are important in visual and olfactory transduction, and possibly in other neuronal functions. These channels have a complex permeability to Ca2+ ions that may be important in their cellular functions. They are composed of two different subunits, alpha and beta, that have been cloned and expressed, but the beta subunit alone cannot be activated by cyclic nucleoti...
The JmjC histone demethylases (KDMs) are linked to tumour cell proliferation and are current cancer targets; however, very few highly selective inhibitors for these are available. Here we report cyclic peptide inhibitors of the KDM4A-C with selectivity over other KDMs/2OG oxygenases, including closely related KDM4D/E isoforms. Crystal structures and biochemical analyses of one of the inhibitors...
Organic molecules with heavy main-group elements frequently form supramolecular links to electron-rich centres. One particular case of such interactions is halogen bonding. Most studies of this phenomenon have been concerned with either dimers or infinitely extended structures (polymers and lattices) but well-defined cyclic structures remain elusive. Here we present oligomeric aggregates of het...
Numerous pharmacological and physiological agents acting via either cAMP- or cGMP-mediated impact the activities of cells of the cardiovascular system. While most define cAMP and cGMP signaling systems as separate and independent, recent advances in our understanding of cyclic nucleotide signaling, and more specifically, of the roles which cyclic nucleotide phosphodiesterases (PDEs) play in the...
The electrochemical behavior of the cation exchange polymer Nation containing tetrathiafulvalenium (TTF +) on a platinum sub strate is described. The polymer electrode shows cyclic voltammetric behavior similar to that of solid films of TTF on platinum. In 1.0M KBr the oxidized form of the electroactive molecules in the polymer (TTF § forms nonstoichiometric complexes with Br-. The peak potenti...
The flavonoids FAA and DMXAA showed impressive activity against solid tumors in mice but failed clinical trials. They act on a previously unknown molecular target(s) to trigger cytokine release from leukocytes, which causes tumor-specific vascular damage and other antitumor effects. We show that DMXAA is a competitive agonist ligand for mouse STING (stimulator of interferon genes), a receptor f...
The intravenous injection of prostaglandin E(1) (PGE(1)) causes a dose-dependent relaxation of the lower esophageal sphincter (LES) in the intact, lightly anesthetized opossum. The action of PGE(1) is not inhibited by the drugs that produce muscarinic or nicotinic cholinergic antagonism or alpha and beta adrenergic antagonism in the doses that inhibited the action of respective agonists. Moreov...
Organic molecules with heavy main-group elements frequently form supramolecular links to electron-rich centres. One particular case of such interactions is halogen bonding. Most studies of this phenomenon have been concerned with either dimers or infinitely extended structures (polymers and lattices) but well-defined cyclic structures remain elusive. Here we present oligomeric aggregates of het...
We extend symbolic protocol analysis to apply to protocols using Diffie-Hellman operations. Diffie-Hellman operations act on a cyclic group of prime order, together with an exponentiation operator. The exponents form a finite field. This rich algebraic structure has resisting previous symbolic approaches. We work in an algebra defined by the normal forms of a rewriting theory (modulo associativ...
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