Leiomyosarcoma is a heterogeneous tumor group, representing <1% of all new cancers diagnosed in United States. Treatment choice is based upon site, grade, and extent of disease. However, prognosis for metastatic or unresectable sarcoma is very poor with reported median survival of 12 months. Response to chemotherapy has been approximately 8% to 39% based upon the chemotherapeutic agent and whet...

Kaposi sarcoma (KS), the most common neoplasm in patients with AIDS, typically presents with multiple skin lesions characterized by "spindle cells," the vast majority of which are infected with KSHV (Kaposi sarcoma herpes virus, also named HHV-8). In patients with AIDS, the presence of cell-associated KSHV DNA in blood is predictive of subsequent KS development, but the mechanisms by which circ...

Phyllodes tumor is an uncommon fibro epithelial breast tumor with diverse biological behavior. The tumor closely resemble as fibroadenoma of the breast. On one end phyllodes is slow growing benign tumor, the other end tumor grows rapidly behave like sarcoma which metastasizes, and phyllodes can turn to frank sarcoma. Tumor can be diagnosed on clinical basis i.e. large mass with lobulated (bosse...

BACKGROUND The aim of this study was to report the effects of a three-drug chemotherapy regimen in patients with symptomatic AIDS-related pulmonary Kaposi's sarcoma and to analyse prognostic factors for survival. METHODS Thirty consecutive HIV seropositive patients with respiratory symptoms and proven pulmonary Kaposi's sarcoma were treated with the same therapeutic regimen comprising adriamy...

RATIONALE Acute promyelocytic leukemia (APL) is a curable subtype of acute myeloid leukemia. APL is currently treated with combination of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) resulting in the induction of apoptosis and differentiation of the leukemic cells. Differentiation syndrome (so-called ATRA syndrome) is the main life-threatening complication of induction therapy with...

Intimal sarcoma (IS) is the most common type of sarcoma of the aorta. IS tumor emboli can involve various organs, including the skin. However, a limited number of IS cases with an initial presentation of skin metastasis has been reported. Cutaneous metastasis as a form of epithelioid angiosarcoma (EAS) has not been well described. Herein, we present a 61-year-old Japanese man with an initial pr...

Histiocytic sarcoma (HS) represents a rare type of malignant disease, characterized by neoplastic proliferation interstitial dendritic cells (iDCs). In rabbits, there are only two previous reports HS with pulmonary and cutaneous primary localizations. A 2-year-old, male, European rabbit (Oryctolagus cuniculus) clinical history chronic respiratory distress progressive weight loss was necropsied....

HHV-8: human herpesvirus-8 KS: Kaposi sarcoma MSM: men who have sex with men INTRODUCTION Kaposi sarcoma (KS) is an indolent angioproliferative tumor thought to be dependent on viral replication, immune modulation, and inflammatory cytokines produced by infected endothelial and immune cells. Human herpesvirus-8 (HHV-8) is thought to cause KS and is documented in more than 95% of patients with K...

BACKGROUND Cutaneous smooth muscle tumors are rare and sometimes the differential diagnosis between leiomyoma and leiomyo-sarcoma is difficult and based in very subtle criteria. We therefore tried to investigate the use of p53 in such a conundrum. This marker has rarely been reported in cutaneous leiomyomas and even in more rare occasions, in cutaneous leiomyomas. MATERIAL AND METHODS We stud...

BACKGROUND The diagnosis of gastrointestinal (GI) involvement in Kaposi's sarcoma (KS) is important to make because the need for treatment depends on the extent of the disease. Moreover, severe GI lesions can cause serious complications. Endoscopy with biopsy is an extremely useful method to diagnose GI-KS. However, determining the indications for endoscopy is difficult because KS can occur wit...