Cutaneous lymphomas comprise a heterogeneous group of lymphoproliferative disorders with skin involvement and are classified as a subgroup of non-Hodgkin lymphomas. From 1981 to 2007, 100 children with non-Hodgkin lymphomas were admitted to the Hematology Unit of the Federal University of Minas Gerais Teaching Hospital. In nine of these children, the skin was involved at the onset of the diseas...

Cutaneous B cell lymphoma (CBCL) is a lymphoproliferative disorder of neoplastic B cell of the skin with a wide range of clinical manifestations. Commonly, the clinical features of CBCL are plaques, nodules, or ulcerative lesions. Skin is one of the common sites for extra-nodal lymphomas in patients with AIDS and B cell type is less common than T cell type. Only recently, the existence of B cel...

BACKGROUND Mucosa-associated lymphoid tissue (MALT) lymphoma is among the most common forms of extranodal lymphomas, but little is known about subcutaneous involvement in patients with non-primary cutaneous marginal zone lymphomas. DESIGN AND METHODS Patients with MALT lymphoma diagnosed and treated at our institution between 1999 and 2010 were analyzed for subcutaneous deposits from MALT lym...

The development of extranodal lymphomas is thought to be initiated by the transformation event in peripheral organs. Lymphomatoid papulosis (LyP) is a low-grade cutaneous lymphoma and may progress into the cutaneous anaplastic lymphoma. We identified 2 patients who 3 and 4 years before the development of LyP were treated for an unrelated malignancy (Burkitt lymphoma and small-cell B-cell lympho...

Originally believed to be of histiocytic origin, regressing primary cutaneous anaplastic large-cell lymphoma is a CD30 (Ki 1) positive T-cell lymphoma with histologic high grade malignancy, but with an often favorable clinical course with regression of individual lesions. We present a case of a 69-year-old white woman with an 8-month history of noduloulcerative lesions on her right lower leg, o...

Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT) is a rare diffuse large B-cell lymphoma confined to the skin of the legs. The typical presentation is characterized by solitary or multiple growing plaques, usually confined to one leg. We report a case of PCDLBCL-LT of activated B-cell subtype characterized by multiple local relapses in the legs, initially, and systemic rel...

CD20+ T cell lymphoma is a rare condition that includes both precursor and peripheral T cell types. However, these cases may be mistaken for T cell marker positive B cell lymphoma, thus creating diagnostic problems with subsequent clinical implications. This report describes a unique case of nodal CD20+ T cell lymphoma with simultaneous cutaneous and subcutaneous involvement. Both nodal and cut...

A Granulomatous lesion in the skin is a common finding and cutaneous lymphoma, although less common, not rare entity. However few case reports exist of granulomatous harboring lymphoma. We present 72-year-old male, with no known co morbidities presenting painless erythematous papules nodules over forehead, trunk limbs since 10 days. The biopsy from showed granulomas along giant cells diffuse mo...

ALCL: anaplastic large cell lymphoma CTCL: cutaneous T-cell lymphoma LyP: lymphomatoid papulosis PCALCL: primary cutaneous anaplastic large cell lymphoma RA: rheumatoid arthritis TNF: tumor necrosis factor INTRODUCTION Antietumor necrosis factor (TNF) agents, such as etanercept, infliximab, and adalimumab, are increasingly used in the treatment of many chronic inflammatory diseases, including p...