What Causes the Acute Blood Pressure Elevation After Stroke? To the Editor: In an insightful editorial1 to a recently published paper by Mattle et al,2 Lindsberg raises a central question as to why blood pressure increases in the acute phase of stroke. The Cushing reflex is suggested as a possible mechanism because it results in sympathetic nervous system activation; however, this reflex is typ...

A great loss has been suffered by our profession, and it is fitting that this Society should pause in its clinical proceedings to pay tribute to Harvey Cushing. In his character and his career was the stuff of which inspiring tradition is made. At the opening of the Montreal Neurological Institute five years ago he was guest speaker and a biographical sketcht appeared in our Foundation Volume. ...

During a 5-year experience with 32 adrenal tumors with different basic problems in the Department of Endocrinology , Taleghani Hospital, 25 were found pituitary dependent Cushing's syndrome, "Cushing's disease." The treatment of patients with Cushing's disease depends on the presence or absence of pituitary tumor. Ifno pituitary tumor is demonstrated, irradiation can be given to the pituit...

Adrenocorticotropin-independent adrenal hyperplasias are rare diseases, which are classified into macronodular (>1 cm) and micronodular (≤1 cm) hyperplasia. Micronodular adrenal hyperplasia is subdivided into primary pigmented adrenocortical disease and a limited or nonpigmented form 'micronodular adrenocortical disease (MAD)', although considerable morphological and genetic overlap is observed...

INTRODUCTION Symptomatic adrenal adenoma usually presents with systemic symptoms. Depending on the function of the adenoma, the patient can present with pheochromocytoma-like symptoms; primary hyperaldosteronism and Cushing syndrome (weight gain, weakness, depression, and bruising). CASE REPORT A 41 year-old lady presented with multiple metatarsal and phalangeal fractures of the both feet wit...

Multiple Endocrine Neoplasia type IIa (MEN IIa) is an autosomal dominant syndrome characterized by pheochromocytoma, medullary thyroid carcinoma and hyperparathyroidism. Pheochromocytoma occurs in approximately 50% of patients with MEN IIa. This tumor has the capacity to produce ACTH ectopically and manifests as the Cushing syndrome, although it is very rare. We report a 26-year-old woman patie...

BACKGROUND Ectopic adrenocorticotropic hormone-producing primary liver tumors are rare, especially in children. We report the case of an adolescent boy of mixed Dutch and Moroccan descent with an adrenocorticotropic hormone-producing calcifying nested stromal-epithelial tumor with long-term follow-up. Thus far, only two such cases have been reported. CASE PRESENTATION A 16-year-old boy of mix...