HP 749 (besipirdine; Hoechst-Roussel Pharmaceuticals, Inc., Somerville, NJ) and related analogs belonging to the N-(4-pyridinyl)-1H-indol-1-amine class of compounds have shown a potential to mitigate multiple biochemical deficits associated with Alzheimer's disease. HP 749 has demonstrated cholinergic and nonadrenergic activities both in vitro and in vivo, and has potential for the symptomatic ...

UNLABELLED BACKGROUND Biotransformation by using microbial and plant cell cultures has been applied effectively for the production of fine chemicals on large scale. Inspired by the wealth of literature available on the biotransformation of steroids, we decided to investigate the biotransformation of ethynodiol diacetate (1) by using plant and microbial cultures. RESULTS The biotransformati...

Several members of the order Mucorales (subphylum Mucoromycotina) are important agents of severe human infections. The identification of these fungi by using standard mycologic methods is often difficult and time consuming. Frequently, the etiological agent in clinical cases is reported either as a Mucor sp., which is not the most frequent genus of zygomycetes, or only as a member of the Mucora...

sclerosis and myocardial infarction. Immunol Cell Biol 2013;91:297–303. 10. HünigT. The stormhas cleared: lessons fromtheCD28 superagonistTGN1412 trial. Nat Rev Immunol 2012;12:317–318. 11. Leuschner F, Rauch PJ, Ueno T, Gorbatov R, Marinelli B, Lee WW, Dutta P, Wei Y, Robbins C, Iwamoto Y, Sena B, Chudnovskiy A, Panizzi P, Keliher E, Higgins JM, Libby P, Moskowitz MA, Pittet MJ, Swirski FK, We...

(+/-)-N-(n-propyl) amphetamine (I), a secondary amine, was readily metabolized by Cumminghamella echinulata. The products included known C- and N-oxygenated mammalian metabolites as well as N-acetylamphetamine and were identified by gas chromatography and mass spectrometry.

Incubations of the fungi Cunninghamella echinulata and Rhizopus oryzae with the sesquiterpene lactones (+)-costunolide (1), (+)-cnicin (2), (+)-salonitenolide (3), (-)-dehydrocostuslactone (4), (-)-lychnopholide (5), and (-)-eremantholide C (6) were perfomed. Incubation of 1 with C. echinulata afforded Delta11(13)-dihydrogenation and Delta1(10)-epoxidation products (7-10). C. echinulata also hy...

When tested as a microbial model for mammalian drug metabolism, the filamentous fungus Cunninghamella elegans metabolized chlorpromazine and methdilazine within 72 h. The metabolites were extracted by chloroform, separated by high-performance liquid chromatography, and characterized by proton nuclear magnetic resonance, mass, and UV spectroscopic analyses. The major metabolites of chlorpromazin...

Infections by Cunninghamella bertholletiae are infrequent but particularly severe and have high associated mortality. Gomes et al.1 reported 6 pediatric cases, 4 with pneumonia and 2 with disseminated disease. In said study, hematologic disease was the majority risk factor. Three patients with lung affectation who underwent surgery and antifungal treatment survived. Our case is a 17-year-old pa...