We present an algorithm for computing the cumulative distribution function of the Kolmogorov{ Smirnov test statistic D n in the all-parameters-known case. Birnbaum (1952) gives an n-fold integral for the CDF of the test statistic which yields a function deened in a piecewise fashion, where each piece is a polynomial of degree n. Unfortunately, it is diicult to determine the appropriate limits o...

BACKGROUND Sensitive screening methods have revealed that many patients have donor-specific human leucocyte antigen antibodies (DSAs) prior to transplantation, regardless of negative crossmatch results. The clinical significance of pre-transplant (pre-Tx) DSAs for early graft function has remained unclear. Our aim was to examine the association of DSAs with delayed graft function (DGF). METHO...

A smooth kernel estimator is proposed for multivariate cumulative distribution functions (cdf), extending the work of Yamato [H. Yamato, Uniform convergence of an estimator of a distribution function, Bull. Math. Statist. 15 (1973), pp. 69–78.] on univariate distribution function estimation. Under assumptions of strict stationarity and geometrically strong mixing, we establish that the proposed...

OBJECTIVE To prospectively investigate the association between serum uric acid (SUA) level and incidence of impaired fasting glucose (IFG) in adult Chinese. METHODS We evaluated 13,328 women and 41,350 men without diabetes and IFG. The participants were classified into quintile according to baseline level of SUA. Data were analyzed to examine the association between SUA levels and the inciden...

BACKGROUND & AIMS Little is known about the incidence of celiac disease in the general population of children in the United States. We aimed to estimate the cumulative incidence of celiac disease in adolescents born in the Denver metropolitan area. METHODS We collected data on HLA-DR, DQ genotypes of 31,766 infants, born from 1993 through 2004 at St. Joseph's Hospital in Denver, from the Diab...

Objective. Although numerous cardiac abnormalities have been reported in HIV-infected children, precise estimates of the incidence of cardiac disease in these children are not well-known. The objective of this report is to describe the 2-year cumulative incidence of cardiac abnormalities in HIV-infected children. Methodology: Design. Prospective cohort (Group I) and inception cohort (Group II) ...

OBJECTIVE Diabetes has been defined as a coronary heart disease (CHD) risk equivalent, and more aggressive treatment goals have been proposed for diabetic patients. RESEARCH DESIGN AND METHODS We studied the influence of single and multiple risk factors on the 10-year cumulative incidence of fatal and nonfatal CHD and cardiovascular disease (CVD) in diabetic and nondiabetic men and women, wit...

Compares the use of relative risk versus population attributable fraction in determining the target population for multirisk prevention programs in psychology. Results show that relative risk generally increases as a function of cumulative risk. Guided by this measure, prevention programs should target populations with the largest cumulative risk. However, relative risk does not account for the...