BACKGROUND Cardiac tropoin I (cTnI) measurements show an approximately 20- to 40-fold difference between assays, and better standardization and harmonization are needed. Toward this goal, the AACC cTnI Standardization Committee collaborated with the National Institute of Standards and Technology (NIST) in an earlier study to select 2 candidate reference materials (cRMs). METHODS Two troponin ...

Patients presenting in the emergency department (ED) with chest discomfort or other symptoms suggestive of acute myocardial infarction (AMI) or unstable angina are at priority for triage and risk stratification. Their treatment is on priority basis and is time bound to have favourable outcome. The goal of door-to-needle time for patient with AMI subjected to fibrinolysis is less than 30 min, wh...

Molybdenum electrode based flexible biosensor on porous polyamide substrates has been fabricated and tested for its functionality as a protein affinity based biosensor. The biosensor performance was evaluated using a key cardiac biomarker; cardiac Troponin-I (cTnI). Molybdenum is a transition metal and demonstrates electrochemical behavior upon interaction with an electrolyte. We have leveraged...

BACKGROUND We sought to determine the diagnostic accuracy of the cardiac troponin I (cTnI) VITROS(R) Troponin I-ES assay for early detection of acute myocardial infarction (AMI) and for risk prediction of adverse events in patients with symptoms of acute coronary syndrome (ACS). METHODS cTnI was measured on admission and approximately 6 h postadmission in 381 patients. The 99th percentile cTn...

BACKGROUND AND PURPOSE Cardiac injury persistence after aneurysmal subarachnoid hemorrhage (aSAH) is not well described. We hypothesized that post-aSAH cardiac injury, detected by elevated cardiac troponin I (cTnI), is related to aSAH severity and associated with electrocardiographic and structural echocardiographic abnormalities that are persistent. METHODS Prospective longitudinal study was...

Objective: Compared with other myocardial enzymes like CK and CK-MB, this study investigates the theoretical basis of whether or not cardiac Troponin I can be used as a diagnostic index of dilated cardiomyopathy. Clinical significance of serum cTnI level of patients with dilated cardiomyopathy (DCM) and its mechanism are studied further. Methods: Firstly, we detected serum cTnI, CK and CK-MB le...

OBJECTIVES Despite several publications on the analytical performance of high-sensitivity cardiac troponin (hs-cTn) assays, there has been little information on how laboratories should validate and implement these assays into clinical service. Our study provides a practical approach for the validation and implementation of a hs-cTn assay across a large North American City. DESIGN AND METHODS ...

BACKGROUND Recent work suggests that increased plasma concentrations of cardiac troponin I (cTnI) are common in critically ill patients and are associated with poor outcome. We measured the frequency of increased plasma cTnI concentrations during patients' stay in a mixed medical/surgical intensive care unit (ICU) and compared our findings with hospital mortality. METHODS Basic details, organ...

BACKGROUND Available assays for cardiac troponin I (cTnI) yield numerically different results. The aim of this study was to compare patient values obtained from four cTnI immunoassays. METHODS We studied the Stratus(R) II assay, the Opus(R) II assay, the Access(R) assay, and a research-only cTnI heterogeneous immunoassay that uses the Dade Behring aca(R) plus immunoassay system equipped with ...

INTRODUCTION The prognostic value of cardiac troponin I (cTnI) in patients having a heat-related illness during a heat wave has been poorly documented. METHODS In a post hoc analysis, we evaluated 514 patients admitted to emergency departments during the August 2003 heat wave in Paris, having a core temperature >38.5 degrees C and who had analysis of cTnI levels. cTnI was considered as normal...