We have previously characterized a number of small molecule organic compounds that prevent the aggregation of the beta-amyloid peptide and its neurotoxicity in hippocampal neuronal cultures. We have now evaluated the effects of such compounds on amyloid precursor protein (APP) accumulation in the CTb immortalized cell line derived from the cerebral cortex of a trisomy 16 mouse, an animal model ...

We propose three improvements to address the drawbacks of state-of-the-art transition-based constituent parsers. First, to resolve the error propagation problem of the traditional pipeline approach, we incorporate POS tagging into the syntactic parsing process. Second, to alleviate the negative influence of size differences among competing action sequences, we align parser states during beam-se...

With the increasing awareness of sustainable mining, cement tailings backfill (CTB) method has been developed rapidly over past decades. In CTB technique, two main mechanical properties engineers were concerned with are rheological slurry and resulting strength after curing. Particle size distribution (PSD) material or PSD is a significant factor that highly influences performance CTB. However,...

Introduction: Cutaneous tuberculosis (CTB) is a rare presentation of extrapulmonary tuberculosis (TB) with various clinical manifestations. Tuberculids, a type of CTB, are probably the result of hyperergic immune reaction induced by Mycobacterium tuberculosis. Lichen scrofulosorum (LS) is a rare tuberculid mostly seen in children and young adults with or without other manifestations of tubercul...

Following intraocular injection of cholera toxin subunit B (CTB), optic afferents to the dorsal pontine region were observed in Mongolian gerbils, Chilean degus, and laboratory rats. CTB-positive optic axons emerge at the caudal pole of the superior colliculus, descend through the periaqueductal gray, and innervate the lateral parabrachial nucleus. This projection appears to be a continuation o...

As mining depth increases, the backfill method is more and widely used in underground mines. The dynamic load generated by blasting can affect stability of cemented tailings (CTB). CTB samples were prepared to conduct a test split Hopkinson pressure bar (SHPB) investigate disturbance CTB. present paper discusses dynamical mechanics, energy dissipation, microstructure analysis Micro-computer tom...

During early gestation, a considerable increase in different leukocyte subsets can be observed in the decidualized endometrium concomitantly to the invasion of cytotrophoblast cells (CTB). To date, it is still in question which factors induce this accumulation of immune cells and whether it is evoked by an in situ proliferation or by a migratory process. Studies on hepatoblastoma cells identifi...

After De΄s pivotal demonstration in 1959 of a diarrhoeogenic exo-enterotoxin in cell-free culture filtrates from Vibrio cholerae (of classical biotype), much insight has been gained about cholera toxin (CT), which is arguably now the best known of all microbial toxins. The subunit structure and function of CT, its receptor (the GM1 ganglioside), and its effects on the cyclic AMP system and on i...

A key molecule in the pathogenesis of Alzheimer's disease (AD) is a 42-amino acid isoform of the amyloid-β peptide (Aβ42), which is the most toxic element of senile plaques. In this study, to develop an edible, safe, low-cost vaccine for AD, a cholera toxin B subunit (CTB)-Aβ42 fusion protein was successfully expressed in silkworm pupae. We tested the silkworm pupae-derived oral vaccination con...

The development of new alternative platforms for subunit vaccine production is a priority in the biomedical field. In this study, Ustilago maydis, the causal agent of common corn smut or 'huitlacoche'has been genetically engineered to assess expression and immunogenicity of the B subunit of the cholera toxin (CTB), a relevant immunomodulatory agent in vaccinology. An oligomeric CTB recombinant ...