نتایج جستجو برای: csb
تعداد نتایج: 628 فیلتر نتایج به سال:
BACKGROUND We previously reported 48-month patency rates of composite sequential bypass (CSB) approaching 60%. Yet, extended patency and limb salvage rates are unknown. HYPOTHESIS Long-term patency and limb salvage rates of CSB are affected by sex, bypass configuration, and warfarin therapy. DESIGN Medical records of all patients who underwent CSB during a 10-year period were retrospectivel...
We report the first investigation of cool-core properties of galaxy clusters selected via their Sunyaev–Zel’dovich (SZ) effect. We use 13 galaxy clusters uniformly selected from 178 deg2 observed with the South Pole Telescope (SPT) and followed up by the Chandra X-ray Observatory. They form an approximately mass-limited sample (>3× 1014 M h−1 70 ) spanning redshifts 0.3 < z < 1.1. Using previou...
BACKGROUND Ready-to-use supplementary food (RUSF) is increasingly used as a component of food rations for adults with HIV. METHODS We undertook a qualitative study to evaluate the acceptability and use of peanut-based RUSF compared to corn-soy blend (CSB) among adults living with HIV in rural Haiti who had been enrolled in a prospective, randomized trial comparing the impact of those rations....
OBJECTIVES Comparison of the immediate and long-term results of three different extrathoracic arterial reconstruction procedures for subclavian obstructive disease. DESIGN Retrospective analysis of 51 extrathoracic subclavian artery reconstructions in 49 patients performed in a single centre over an 18-year period (mean follow-up 64 months, range 3-192). METHODS Carotid-subclavian bypass (C...
For pilot or experimental employment programme results to apply beyond their test bed, researchers must select 'clusters' (i.e. the job centres delivering the new intervention) that are reasonably representative of the whole territory. More specifically, this requirement must account for conditions that could artificially inflate the effect of a programme, such as the fluidity of the local labo...
Cockayne syndrome is a neurodegenerative accelerated aging disorder caused by mutations in the CSA or CSB genes. Although the pathogenesis of Cockayne syndrome has remained elusive, recent work implicates mitochondrial dysfunction in the disease progression. Here, we present evidence that loss of CSA or CSB in a neuroblastoma cell line converges on mitochondrial dysfunction caused by defects in...
We propose a new approach to determine the strength of charge symmetry breaking (CSB) term in framework nuclear density functional theory. It is shown that once ab initio calculations are available including accurate description isospin terms medium and heavy nuclei, mass difference mirror nuclei as well neutron-skin thickness doubly-closed-shell can be used constrain CSB interaction with an un...
Cockayne syndrome (CS) is a severe neurodevelopmental disorder characterized by growth abnormalities, premature aging, and photosensitivity. Mutation of Cockayne syndrome B (CSB) affects neuronal gene expression and differentiation, so we attempted to bypass its function by expressing downstream target genes. Intriguingly, ectopic expression of Synaptotagmin 9 (SYT9), a key component of the mac...
The human mitochondrial transcription machinery generates the primers required for initiation of leading-strand DNA replication. According to one model, the 3' end of the primer is defined by transcription termination at conserved sequence block II (CSB II) in the mitochondrial DNA control region. We here demonstrate that this site-specific termination event is caused by G-quadruplex structures...
We investigated the question if CSB (Cockayne Syndrome complementation B) protein actively regulates gene transcription and how mutations in CSB gene affect that regulatory role. Here we describe how we processed and interpreted ChIP-seq data (deposited in Gene Expression Omnibus with accession number GSE50171) obtained during an investigation of that question, and how this analysis assisted in...
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