Poly-L-lactic acid (PLLA) electrospun nanofiber scaffold is one of the most commonly used synthetic polymer scaffolds for bone tissue engineering application. However, PLLA is hydrophobic in nature, hence does not maintain proper cell adhesion and tissue formation, moreover, it cannot provide the osteo-inductive environment due to inappropriate surface characteristic and the lack of surface mot...

Poly(L-lactic acid) (PLLA) was immersed in a simulated body fluid (SBF) solution at 37.58C for distinct times. The variation of the surface mechanical properties of PLLA samples with immersion time was followed by microhardness. These measurements showed that PLLA microhardness decreased significantly ( 60%) after only 30 days of immersion. The results were explained in terms of hydrolytic degr...

BACKGROUND Two methoxyl poly(ethylene glycol)-poly(L-histidine)-poly(L-lactide) (mPEG-PH-PLLA) triblock copolymers with different poly(L-histidine) chain lengths were synthesized. The morphology and biocompatibility of these self-assembled nanoparticles was investigated. METHODS Doxorubicin, an antitumor drug, was trapped in the nanoparticles to explore their drug-release behavior. The drug-l...

Background: Polyesters have been attractive for development of drug delivery applications because of their biocompatible, biodegradable and non-toxic properties. The objective of work is a comparative study on the release characteristics of two drugs loaded poly (L-lactide) (PLLA) film. Progesterone (Pro) and lidocaine hydrochloride (LidH) were chosen as the hydrophobic and hydrophilic model dr...

In bone engineering, the adhesion, proliferation and differentiation of mesenchymal stromal cells rely on signaling from chemico-physical structure of the substrate, therefore prompting the design of mimetic "extracellular matrix"-like scaffolds. In this study, three-dimensional porous poly-L-lactic acid (PLLA)-based scaffolds have been mixed with different components, including single walled c...

By reaction of poly(L-lactic acid) (PLLA) membrane with 1,6-hexanediamine, free amino groups were introduced onto a PLLA surface, through which biocompatible macromolecules such as gelatin, chitosan, or collagen were covalently immobilized by employing glutaraldehyde as a coupling agent. The existence of free amino groups on the aminolyzed PLLA surface was verified quantitatively by the ninhydr...

For the purpose of obtaining high bone forming efficacy, development of chitosan was attempted as a tool useful as a scaffolding device. Porous chitosan matrices, chitosan-poly(L-lactide) (PLLA) composite matrices and chitosan coated on PLLA matrices were dealt with in this research. Porous chitosan matrix was fabricated by freeze-drying and cross-linking aqueous chitosan solution. Porous chito...

The modified poly(L-lactic acid) (PLLA) with different contents (0.5−3 wt %) of N,N’-bis(phenyl) 1,4-naphthalenedicarboxylic acid dihydrazide (NAPH) were prepared to evaluate effects NAPH on melt-crystallization behavior (DSC), thermal degradation (TGA) and mechanical properties PLLA. results demonstrated that as a heterogeneous organic nucleating agent enhanced crystallization ability PLLA in ...

Poly (3-hydroxy butyrate) (PHB), cellulose nano crystal (CNC) and a plasticizer (TBC) are mixed together with PLLA with the aim to increase the elongation at break for use in the food packing sector. Spherical (CNC) and fibril nano crystal (CNF) were prepared by hydrolysis of microcrystalline cellulose (MCC) in distilled water, and then stirred using a magnetic stirrer for 15 days and ultrasoni...