To investigate the biological activities of anthocyanins, which are induced by cadmium in A. imbricata, the antioxidant properties of anthocyanins were investigated using various antioxidant assays, namely 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, 2,2'-azinobis-(3-ethylbenzthiazoline-6sulfonic acid) (ABTS) radical scavenging activity, reducing power, and β-carotene bleac...

The essential oil of Verbena officinalis growing in Iran was extracted using hydro-distillationmethod and the antibacterial and antioxidant activities were evaluated. The antibacterial activity of the essentialoil against a Gram-positive (S. aureus ATCC25923) and Gram negative (E. coli ATCC 25922) were examined.The results obtained revealed that the essential oil exhibited variable levels of an...

PURPOSE Chronic stress has been reported to induce oxidative damage of the brain. A few studies have shown that Crocus Sativus L., commonly known as saffron and its active constituent crocin may have a protective effect against oxidative stress. The present work was designed to study the protective effects of saffron extract and crocin on chronic - stress induced oxidative stress damage of the ...

BACKGROUND Crocin and safranal are the active substances of saffron and have many biological properties. In the present study, we compared the effects of crocin, safranal and diclofenac on local inflammation and its induced pain in rats. METHODS Local inflammation was induced by intraplantar (ipl) injection of carrageenan (100 μl, 2%). Paw thickness was measured before and after carrageenan i...

Post-traumatic stress disorder (PTSD) occurs following life-threatening events. The activity of the hypothalamic-pituitary-adrenal (HPA) axis, which serves as the first line of defense against stress, is dysfunctional in this disorder. The current study aimed to investigate the role of Crocin in normalizing HPA function in an animal model of PTSD induced by electric foot shock. Rats were treate...

BACKGROUND Saffron is the dried stigma of Crocus sativus L. flower which commonly used as a natural remedy to enhance health and even fights disease in the Middle-East and Southeast Asian countries. METHODS This study was aimed to investigate protective effect of saffron extract and crocin in fatty liver tissue of high-fat diet induced obese rats. A total of 36 healthy male Sprague Dawley r...

The ethanolic extract of Aloe vera leaf skin was fractionated by liquid-liquid partition using hexane, ethyl acetate, chloroform-ethanol and butanol. The total phenolic content of the four different fractions were determined by Folin-Ciocalteu method and their antioxidant activity was essayed through some in vitro models such as the antioxidant capacity by phosphomolybdenum method, β-carotene b...

objective(s):alzheimer's disease (ad) is the most common age-related neurodegenerative disorder. one of the hallmarks of ad is an abnormal accumulation of fibril forms of tau protein which is known as a microtubule associated protein. in this regard, inhibition of tau aggregation has been documented to be a potent therapeutic approach in ad and tauopathies. unfortunately, the available syn...

crocin, a bioactive molecule of saffron can be purely isolated from the saffron extract. it has different pharmacological effects such as antioxidant and anticancer activities. morphine is an opioid analgesic drug. it is mainly metabolized in liver and causes devastating effects. it can increase the generation of free radicals. this study was designed to evaluate the protective role of crocin a...

objective: crocin and safranal are the main components of saffron, and have many biological functions such as anti-inflammatory and antioxidant activities. in the present study, we investigated the effects of crocin, safranal, morphine, diclofenac and naloxone in combined and separately on formalin-induced orofacial pain in rats. materials and methods: subcutaneous injection of a diluted formal...