BACKGROUND Appropriate treatment of osteonecrosis of femoral head (ONFH) remains challenging. OBJECTIVES Here, we report the results of treating these patients with auto-corticocancellous bone graft from iliac crest to overcome the need for early total hip arthroplasty (THA). PATIENTS AND METHODS There were 132 hips (96 patients) with ONFH. Association Research Circulation Osseous (ARCO) ty...

the normal and lateral line cycloid scales of the native species garra rossica (nikol’skii, 1900), one of the most common and poorly known cyprinid fish in south-eastern iran have been subjected to the scanning electron microscopy technique in order to study their detailed structure. normal scale below the dorsal fin showed a clearcut demonstration between the anterior and posterior region with...

A sub-population of the neural crest is known to play a crucial role in development of the cardiac outflow tract. Studies in avians have mapped the complete migratory pathways taken by 'cardiac' neural crest cells en route from the neural tube to the developing heart. A cardiac neural crest lineage is also known to exist in mammals, although detailed information on its axial level of origin and...

Previous studies showed that conotruncal heart malformations can arise with the increase or decrease in alpha1 connexin function in neural crest cells. To elucidate the possible basis for the quantitative requirement for alpha1 connexin gap junctions in cardiac development, a neural crest outgrowth culture system was used to examine migration of neural crest cells derived from CMV43 transgenic ...

The flow characteristics and vortex evolution behind a circular cylinder near wavy wall are studied using large-eddy simulation framework. Reynolds number based on the diameter D is Re = 1500, gap ratio G/ fixed to 1, slope S λ/2 k varies from 2 8 (where G distance between lower surface of crest, λ wavelength, wave amplitude). field characteristics, hydrodynamic coefficients, pressure distribut...

Transcription factors regulate tissue patterning and cell fate determination during development; however, expression of early regulators frequently abates upon differentiation, suggesting that they may also play a role in maintaining an undifferentiated phenotype. The transcription factor paired box 3 (Pax3) is expressed by multipotent neural crest precursors and is implicated in neural crest d...

Recent studies have shown that adipose-derived stromal/stem cells (ASCs) contain phenotypically and functionally heterogeneous subpopulations of cells, but their developmental origin and their relative differentiation potential remain elusive. In the present study, we aimed at investigating how and to what extent the neural crest contributes to ASCs using Cre-loxP-mediated fate mapping. ASCs ha...

Previous studies have shown that ablation of cranial neural crest results in heart malformations in chick embryos. Cranial neural crest cells populate all of the pharyngeal arches and provide the mesenchymal walls of the aortic arch arteries. Neural crest cells migrate from the pharyngeal apparatus into the outflow region of the heart. However, it is not known which of the pharyngeal arches con...

Cardiac neural crest cells are essential for outflow tract remodeling in animals with divided systemic and pulmonary circulatory systems, but their contributions to cardiac development in animals with a single-loop circulatory system are less clear. Here we genetically labeled neural crest cells and examined their contribution to the developing zebrafish heart. We identified two populations of ...

BACKGROUND Neural crest cells are vertebrate-specific multipotent cells that contribute to a variety of tissues including the peripheral nervous system, melanocytes, and craniofacial bones and cartilage. Abnormal development of the neural crest is associated with several human maladies including cleft/lip palate, aggressive cancers such as melanoma and neuroblastoma, and rare syndromes, like Wa...