نتایج جستجو برای: creb1
تعداد نتایج: 411 فیلتر نتایج به سال:
Sir: Twin recent reports identified a novel entity, primary pulmonary myxoid sarcoma (PPMS) and an endobronchial presentation of angiomatoid fibrous histiocytoma (AFH). PPMS were described as 20– 40-mm diameter endobronchial, lobulated neoplasms occurring in young patients (mean age 45 years), and comprising polygonal to spindled cells within a myxoid stroma evocative of extraskeletal myxoid ch...
The sensorimotor synapse of Aplysia exhibits long-term facilitation (LTF) and long-term depression (LTD) elicited by the neuromodulator serotonin (5-HT) and the peptide Phe-Met-Arg-Phe-NH(2), respectively. 5-HT-induced LTF engages extracellular-regulated kinase (Erk) and CREB1, whereas FMRFa-induced LTD engages p38 MAPK (mitogen-activated protein kinase) and CREB2. The interaction of the 5-HT a...
We have developed a protein knockdown technology using hybrid small molecules designed as conjugates of a ligand for the target protein and a ligand for ubiquitin ligase cellular inhibitor of apoptosis protein 1 (cIAP1). However, this technology has several limitations. Here, we report the development of a novel protein knockdown system to address these limitations. In this system, target prote...
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