Amoxicillin pharmacokinetics after intravenous administration were studied in patients with normal renal function, with impaired renal function, and during hemodialysis. The average urinary recovery was 68% in patients with normal renal function. Serum half-life was highly correlated (r = 0.967) with creatinine clearance corrected for body weight. Expected half-life was 71 min for a corrected c...

Fluid management and dosage regimens of drugs in preterm infants should be based on the glomerular filtration rate. The current methods to determine glomerular filtration rate are invasive, time-consuming, and expensive. In contrast, creatinine clearance can be easy obtained and quickly determined. The purpose of this study was to compare plasma creatinine on the third and seventh day of life i...

BACKGROUND Serum creatinine concentration is widely used as an index of renal function, but this concentration is affected by factors other than glomerular filtration rate (GFR). OBJECTIVE To develop an equation to predict GFR from serum creatinine concentration and other factors. DESIGN Cross-sectional study of GFR, creatinine clearance, serum creatinine concentration, and demographic and ...

BACKGROUND Reduced renal function is an established risk factor for cardiovascular events. We compared 3 measures of renal function--serum cystatin C, serum creatinine, and calculated creatinine clearance--as predictors of subsequent cardiovascular events in a community-based population of elderly individuals. METHODS Comprehensive cardiovascular risk factor data were available for 1410 survi...

Expanded criteria donor kidneys (ECD) have the potential to greatly increase the number of kidneys available for transplantation; however utilization is limited by poorer outcomes [1-5]. One strategy to improve outcomes and secondarily utilization is improved matching of kidneys based on recipient factors such as surface area [6,7], kidney graft size to recipient weight [8] and kidney weight to...

A prospective study of the kidney function of chimpanzees (Pan troglodytes) kept at the Hans Popper Primate Centre has been performed within the last 10 years. The aim of the study was to analyse urine samples for specific gravity, to determine serum creatinine, serum urea, and urinary creatinine, and to calculate creatinine clearance and reference values for healthy chimpanzees. From 1750 urin...

The existing methods for the analysis of inulin, as well as the requirements for the continuous intravenous infusion of this material, place the inulin clearance method for measuring the glomerular filtration rate beyond the reach of practicality for many laboratories and in general limit clearance observations to relatively short intervals of time. There is a requirement for a simpler clearanc...

Abstract Objective This study aimed to evaluate the effect of swimming training (T) on renal system and body composition parameters in young animals treated with a high sucrose diet (SUD) during 12 weeks. Results The SUD impaired physical performance, increased adiposity index (BAI), Lee (LI) retroperitoneal adipose tissue (RAT) weight, plasma creatinine number cells nuclei, decreased urinary v...

To the Editor: In a recent report (1 ), we provided data on the early follow-up of renal function by plasma cystatin C in transplanted adults. Cystatin C was found to be an alternative and more sensitive marker of acute changes in glomerular filtration rate (GFR) than plasma creatinine, especially during acute rejection episodes. We present here some additional data on the same group of patient...

BACKGROUND There is a significant need to estimate creatinine clearance easily in acutely ill patients with unstable renal function, who have rapidly changing serum creatinine values and who need careful individualization of drug dosage, all without the problems associated with having to collect the traditional carefully timed urine specimen. METHOD The daily change in the total amount of cre...