Colorectal cancer (CRC) is the second most common cancer in Western countries. Hereditary forms only correspond to 5% of CRC burden. Recently, genome-wide association studies have identified common low-penetrant CRC genetic susceptibility loci. Early-onset CRC (CRC<50 years old) is especially suggestive of hereditary predisposition although 85-90% of heritability still remains unidentified. CRC...

Full Professor Math. & Indus. Eng., École Polytechnique de Montréal, 06/2007–... Director GERAD research center, Montréal, 05/2015–... Associate Professor Math. & Indus. Eng., École Polytechnique de Montréal, 06/2001–05/2007 Assistant Professor Math. & Indus. Eng., École Polytechnique de Montréal, 12/2000–06/2001 Researcher Math. & Indus. Eng., École Polytechnique de Montréal, 08/1999–11/2000 A...

A mathematically correct form of the linear storage element’s routing equation is specified requiring only a slight modification of the existing HEC-HMS routine. The new formulation, unlike the current version in use, is unconditionally stable as long as the time step and the storage coefficient values are trivially specified as positive numbers.

BACKGROUND Patients with ulcerative colitis (UC) are predisposed to colitis-associated colorectal cancer (CAC). However, the transcriptional mechanism of the transformation from UC to CAC is not fully understood. METHODOLOGY Firstly, we showed that CAC and non-UC-associated CRC were very similar in gene expression. Secondly, based on multiple datasets for UC and CRC, we extracted differential...

Israeli Arabs have been at low risk for colorectal cancer (CRC) and had mainly proximal cancer, but increasing CRC is now noted. We examined this trend and CRC site and compared them to the total Jewish population and to the low-risk Jews of Asian-African origin. Israel Cancer Registry CRC data, 1982-2002, for Arabs and Jews was computed by gender, age and site: rectal cancer included recto-sig...

BACKGROUND Familial occurrence is common in colorectal cancer (CRC), but whether this increased familial risk differs by colonic subsite of the index patients CRC is not well understood. AIM To quantify the risk of CRC in first-degree (FDR), second-degree (SDR) and first cousin (FC) relatives of individuals with CRC, stratified by subsite in the colorectum and age at diagnosis. METHODS Colo...

BACKGROUND Angiopoietin-like protein 1 (ANGPTL1) has been reported to suppress migration and invasion in lung and breast cancer, acting as a novel tumor suppressor candidate. Nevertheless, its effects on colorectal cancer (CRC) remain poorly defined. In this study, we aim to demonstrate the biological function of ANGPTL1 in CRC cells. METHODS We explored ANGPTL1 mRNA expression in human CRC t...

CRC cards are unconventional method for identifying and describing classes, behavior and its responsibilities and collaborators of class. Representation of three categories of class, responsibilities and collaborators can give proper image of scenario. These cards are effective method for analyzing scenarios. With all positive features of CRC cards, of weaknesses of these cards are failure to s...

This paper presents how to compute n-bit CRC checksums on FPGAs in parallel. For this task, a specialized logic minimization strategy is outlined. It achieves signiicantly better results than standard logic optimizers. For n 96, CRC designs with an n-bit I/O interface are poorly routable. However, for smaller I/O interfaces even a 128-bit CRC can be implemented.