PURPOSE To validate the recorded diagnoses of colorectal cancer (CRC) and identify false negatives in The Health Improvement Network (THIN) primary care database. METHODS We conducted a validation study of incident CRC cases in THIN among patients aged 40-89 years from 2000-2011. CRC Read code entries (N = 3805) were verified by manual review of patients' electronic medical records (EMRs) inc...

background: â  colorectal cancer (crc) is one of the most common invasive cancers responsible for physical and psychosocial morbidity. therefore, quality of life (qol) is an important outcome for these patients. despite advances in understanding qol, the majority of available research is from urban areas. the present study aims to compare qol between urban and rural crc patients. â  materials a...

aim : we aimed to explore the frequency of braf v600e mutation in iranian patients with colorectal cancer (crc) as well as its association with clinic pathological characteristic of patients.   background : crc is the third leading cause of cancer related death. there is a growing body of data showing the association of braf v600e mutation with malignant transformation and clinical outcome of d...

Cyclic Redundancy Checks (CRC) constitute an important class of hash functions for detecting changes in data blocks after transmission, storage and retrieval, or distributed processing. Currently, most sequential methods based on Horner’s scheme are applied with some extensions or modifications. The flexibility of these methods with respect to the generator polynomial and the sequence of data p...

BACKGROUND & AIMS Patients diagnosed with colorectal cancer (CRC) are at risk for synchronous and metachronous lesions at the time of diagnosis or during follow-up evaluation. We performed a population-based study to evaluate the rate, predictors, and familial risk for synchronous and metachronous CRC in Utah. METHODS All newly diagnosed cases of CRC between 1980 and 2010 were obtained from t...

objective: colorectal cancer (crc) is one of the most common and aggressive cancers worldwide. the majority of crc cases are sporadic that caused by somatic mutations. the adenomatous polyposis coli (apc; omim 611731) is a tumor suppressor gene of wnt pathway and is frequently mutated in crc cases. this study was designed to investigate the spectrum of apc gene mutations in iranian patients wit...

In this study, we investigated the role of galectin-3 and carcinoembryonic antigen (CEA) in metastasis and survival of colorectal cancer (CRC) patients. CEA interacted with galectin-3 at the cell surface and cytoplasm of Caco2 and DLD1 CRC cells. Knocking down galectin-3 did not affect CEA expression in CRC cells. However, there was a dose-dependent increase in CRC cell migration upon addition ...

Background: Bioinformatic approaches for designing vaccines have become a promising alternative to conventional methods. We herein designed a multi-epitope-based vaccine against colorectal cancer (CRC). Methods: Used peptides in the CRC vaccines were retrieved from databases of PubMed, Web of Science, Google Scholar, and Clinical trials. The adjuvants of Mycobacterial heparin-binding hemagglut...

Colorectal Cancer (CRC) is the second most common cancer in women and third men. There strong evidence for role of Stem Cells (CSCs) progression. The identification understanding CSCs genes such as LGR5 involved induction development crucial prognosis CRC. a membrane protein several molecular signaling pathways, Wnt NOTCH pathways. It has been shown that gene was overexpressed CRC associated wi...