BRIEF REPORT Authors Erwin Kemna, Harold Tjalsma, Coby Laarakkers, Elizabeta Nemeth, Hans Willems, Dorine Swinkels Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. Corresponding author Erwin H.J.M. Kemna Department of Clinical Chemistry...

In pharmaceutical industries, the validation of analytical methods is used to demonstrate that the method is fitted for its purpose; it must follow a plan which includes scope, performance characteristics, and acceptance limits. Analytical methods need to be validated or revalidated prior to their introduction into routine analyses (release of batch). The overarching philosophy in current good ...

For a labelled tree on the vertex set [n] := {1, 2, . . . , n}, define the direction of each edge ij to be i → j if i < j. The indegree sequence of T can be considered as a partition λ ⊢ n − 1. The enumeration of trees with a given indegree sequence arises in counting secant planes of curves in projective spaces. Recently Ethan Cotterill conjectured a formula for the number of trees on [n] with...

In [13] a homology theory –Morse-Conley-Floer homology– for isolated invariant sets of arbitrary flows on finite dimensional manifolds is developed. In this paper we investigate functoriality and duality of this homology theory. As a preliminary we investigate functoriality in Morse homology. Functoriality for Morse homology of closed manifolds is known [1, 2, 3, 8, 14], but the proofs use isom...

n engl j med nejm.org 1 From Fundação Oswaldo Cruz, Rio de Janeiro (P.B., J.P.P.J., L.D., M.W., R.M.R.N., P.C.S., A.M.S., L.M.A.C., D.C.C., G.A.C., E.S.N., M.E.M., A.E.R.B., P.R.N.C., A.M.B.F.); Biomedical Research Institute of Southern California, Oceanside (C.R.G.); and David Geffen UCLA School of Medicine, Los Angeles (C.J., S.G.V., J.D.C., K.N.-S.). Address reprint requests to Dr. NielsenSa...

just like any other process, vaccine manufacturing procedures are defined as a series of interrelated functions and activities using a variety of specified actions and equipment designed to produce a defined product. to assure the reproducibility and consistency of such processes, they must be carried out using validated equipment and under the established procedures that meet all the acceptanc...

1. I n t roduc t i on Discrete Morse theory was developed by Forman [9, 11] as a combinatorial analog to the classical smooth Morse theory. Applications to questions in combinatorial topology and related fields are numerous: e.g., Babson et al. [3], Forman [10], Batzies and Welker [4], and Jonsson [20]. I t turns out that the topologically relevant information of a discrete Morse function f on ...