Opening of CLC chloride channels is coupled to the translocation of the permeant anion. From the recent structure determination of bacterial CLC proteins in the closed and open configuration, a glutamate residue was hypothesized to form part of the Cl--sensitive gate. The negatively charged side-chain of the glutamate was suggested to occlude the permeation pathway in the closed state, while op...

Background Hemangioblastomas are the most common primary tumor of the posterior fossa. There are few cases of hemangioblastoma of the cerebellopontine angle (CPA). When present in this location, hemangioblastoma presents a diagnostic challenge as its imaging findings closely resemble those of vestibular schwannoma (VS), which is much more common in the CPA. Case Description We report the case...

Clinical trials are testing oncolytic viruses (OVs) as therapies for cancer. We have shown that animals that have brain tumors and are treated with a herpes simplex virus (HSV)-derived OV live significantly longer when cyclophosphamide (CPA) is preadministered. Here, we explore the mechanisms behind this finding. In a syngeneic rat glioma model, intratumoral HSV administration is associated wit...

Consider Pr [ A( ,Uk,·) ( 1, E ( 1,Uk,m k )) = 1 ] for b = 0, 1 (we will refer to this as Pr [A0] and Pr [A1] for convenience). Suppose that the oracle is queried at most p (k) times for some polynomial p (k). The i-th time the oracle is queried, it picks some random c0 (call it ci,0) and then returns ci,0,Uk (ci,0) ⊕m. Let E be the event that ci,0 = c 0 for any i. Since each ci,0 is chosen at ...

BACKGROUND The aim of this study was to compare the diagnostic performances of the collagen proportionate area (CPA) and liver stiffness measurement (LSM) for liver fibrosis quantification in chronic hepatitis C (CHC). METHODS A total of 137 eligible consecutive Taiwanese patients (74 women and 63 men; age 21-80 years; median age 54 years), with CHC underwent LSM by using acoustic radiation f...

The effects of cyclopiazonic acid (CPA), a known Ca2'-pump inhibitor at internal stores, were investigated on electrical responses of the membrane of smooth muscle cells in small segments (O.3-O.5 mm long) of circular smooth muscle isolated from the guineapig gastric antrum. In most preparations, the membrane was spontaneously active with the generation of unitary potentials and regenerative sl...

We consider the Secure Broadcast problem in incomplete networks. We study the resilience of the Certified Propagation Algorithm (CPA), which is particularly suitable for ad hoc networks. We address the issue of determining the maximum number of corrupted players t max that CPA can tolerate under the t-locally bounded adversary model, in which the adversary may corrupt at most t players in each ...

The aim of this study was to identify the effects highly dispersed silica nanoparticles (HDSns) on cryoresistance Ovis Aries cumulus oocytes in conditions intra-(IOV) or extra-(EOV) ovarian vitrification. Materials and methods. Cumulus-oocyte complexes (COC) intended for EOV were treated with solutions cryoprotectants (CPA) prepared TC-199 10% FBS (fetal bovine serum): CPA-1-0.7 M dimethyl sulf...

Draft of March 11, 2001. We still plan to make considerable changes to this manuscript. Comments and list of typos are welcome!