with steroidal and non-steroidal anti inflammatory drugs (NSAIDs). NSAIDs are drug with analgesic, antipyretic and in higher doses anti inflammatory effects. They inhibit synthesis of inflammation mediators. Most NSAIDs act as non-selective inhibitors of the enzyme cyclooxygenase (COX), by inhibiting the metabolism of arachidonic acid. COX catalyses the formation of prostaglandins (PGs) and thr...

Aspirin has been on the market for 115 years. Beginning with the marketing of indomethacin for the treatment of rheumatoid arthritis in 1963, at least 20 other nonsteroidal anti-inflammatory drugs (NSAIDs) with aspirin-like actions have been developed over the past 50 years, culminating with the introduction of a new class of selective inhibitors of cyclooxygenase (COX)-2, the coxibs, approxima...

Non Steroid Anti-Inflammatory Drugs (NSAIDs) have been the treatment of choice for mild to moderate inflammatory pain for more than a century. NSAIDs block the formation of prostaglandins by inhibiting cyclooxygenase (COX). Their most common side-effect is ulceration of the upper gastrointestinal tract. The development of selective COX-2 inhibitors (coxibs) has reduced gastrointestinal toxicity...

Expression of cyclooxygenase-2 (COX-2) is involved in the chronic inflammation-related development of Barrett's adenocarcinoma and the use of selective COX-2 inhibitors (coxibs) might provide new chemoprevention strategy for Barrett's adenocarcinoma (BA). Despite an excellent gastrointestinal (GI) safety profile of coxibs, their use is limited because of the possible cardiovascular complication...