نتایج جستجو برای: cox transformation

تعداد نتایج: 269166  

ژورنال: :پژوهش در پزشکی 0
رویا شریفی sharifi r 1 department of clinical biochemistry, faculty of medicine, tehran university of medical scienceگروه بیوشیمی بالینی، دانشکده پزشکی، دانشگاه علوم پزشکی تهران مهدی هدایتی hedayati m endocrine research center, shahid beheshti medical universityمرکز تحقیقات چاقی، پژوهشکده علوم غدد درون ریز، دانشگاه علوم پزشکی شهید بهشتی یوسف رسمی rasmi y department of clinical biochemistry, tarbiat modarres universityگروه بیوشیمی بالینی، دانشکده پزشکی ،دانشگاه تربیت مدرس محمد رحمتی یامچی rahmati-yamchi m department of clinical biochemistry, tarbiat modarres universityگروه بیوشیمی بالینی، دانشکده پزشکی ،دانشگاه تربیت مدرس فائزه فاطمی fatemi f department of clinical biochemistry, tarbiat modarres universityگروه بیوشیمی بالینی، دانشکده پزشکی ،دانشگاه تربیت مدرس ابوالفضل دادخواه dadkhah a department of clinical biochemistry, tarbiat modarres universityگروه بیوشیمی بالینی، دانشکده پزشکی ،دانشگاه تربیت مدرس عبدالامیر علامه

است. هر دو cox- و 2 cox- آنزیمی کلیدی در تبدیل اسید آراشیدونیک به پروستاگلاندینها و دارای دو ایزوزیم 1 (cox) سیکلواکسیژناز در اکثر بافتها بطور cox- ایزوزیم بهوسیله داروهای ضد التهابی غیر استروئیدی نظیر ایندومتاسین و ایبوپروفن مهار میشوند. آنزیم 1 به عنوان جزئی از واکنش های التهابی در cox- پیوسته بیان می شود و در عملکردهای فیزیولوژیک دخیل است، در حالی که آنزیم 2 با التهاب، درد، ر گزایی، cox- پاس...

Journal: :The Journal of clinical investigation 2006
Tilo Grosser Susanne Fries Garret A FitzGerald

Inhibitors selective for prostaglandin G/H synthase-2 (PGHS-2) (known colloquially as COX-2) were designed to minimize gastrointestinal complications of traditional NSAIDs--adverse effects attributed to suppression of COX-1-derived PGE2 and prostacyclin (PGI2). Evidence from 2 randomized controlled-outcome trials (RCTs) of 2 structurally distinct selective inhibitors of COX-2 supports this hypo...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2001
K Valmsen I Järving W E Boeglin K Varvas R Koljak T Pehk A R Brash N Samel

The highest concentrations of prostaglandins in nature are found in the Caribbean gorgonian Plexaura homomalla. Depending on its geographical location, this coral contains prostaglandins with typical mammalian stereochemistry (15S-hydroxy) or the unusual 15R-prostaglandins. Their metabolic origin has remained the subject of mechanistic speculations for three decades. Here, we report the structu...

A new series of imidazo[2,1-b]thiazole analogs containing a methyl sulfonyl COX-2 pharmacophore was synthesized and evaluated for their COX-2 inhibitory activity. According to in-vitro COX-1/COX-2 inhibition data, all compounds (6a-g) were selective inhibitors of COX-2 isoenzyme with IC50 values in the highly potent 0.08-0.16 mM range. These results indicated that both potency and selectivity o...

Cyclooxygenase-2 (COX-2) has a pivotal role in the pathogenesis of the lung cancer. It is known that COX-2 negatively regulates the activity of a number of tumor suppressors, including p53. Consequently, inhibition of COX-2 signaling is anticipated to be a promising approach to stabilize p53 functionality. In this regard, we investigated the effect of COX-2 signaling blockade on p53 and COX-2 e...

Journal: :Statistics in medicine 2006
David M Zucker Song Yang

For survival data regression, the Cox proportional hazards model is the most popular model, but in certain situations the Cox model is inappropriate. Various authors have proposed the proportional odds model as an alternative. Yang and Prentice recently presented a number of easily implemented estimators for the proportional odds model. Here we show how to extend the methods of Yang and Prentic...

Journal: :Neurology 2005
M Eurelings H M Lokhorst S Kalmijn J H J Wokke N C Notermans

OBJECTIVE To assess the frequency of hematologic malignancies at diagnosis and to determine the incidence and predictors of malignant transformation during follow-up in patients with polyneuropathy associated with monoclonal gammopathy. METHODS Potential predictors of malignant transformation from medical history, hematologic, neurologic, and laboratory examination performed each 6 months wer...

A group of regioisomeric 5-oxo-1,4,5,6,7,8 hexahydroquinoline derivatives possessing a COX-2 SO2Me pharmacophore at the para position of the C-2 or C-4 phenyl ring, in conjunction with a C-4 or C-2 phenyl (4-H) or substituted-phenyl ring (4-F,4-Cl,4-Br,4-OMe,4-Me, 4-NO2), were designed for evaluation as selective cyclooxygenase-2 (COX-2) inhibitors. These target 5-oxo-1,4,5,6,7,8 hexahydroquino...

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