background: the incidence of restenosis in patients suffering from coronary artery disease after undergoing angioplasty is of paramount importance. accordingly, this study aimed to investigate factors affecting the time of the first incidence of restenosis in patients undergone angioplasty in the city of zanjan, iran.   methods: this retrospective cohort study was conducted on 421 patients who ...

this study was designed to investigate causes of culling in industrial dairy herds in fars province and to describe the pattern of reason-specific culling with respect to age of animal and interval from calving to culling. a total number of 9 dairy herds were selected for the study and information about culling reasons, birth date, last calving date and culling date was collected for culled cow...

inhibition of prostaglandin (pgs) production leads to decrease in orthodontic tooth movement (otm). it is not known whether inhibition of cyclooxygenase-1 (cox-1) or cyclooxygenase-2 (cox-2) is the key mechanism for this effect. in this study, the effect of celecoxib, a highly-selective cox-2 inhibitor, was investigated on otm in rats.four groups of male rats (seven animals in each goup) were u...

Cyclooxygenases (COX, prostaglandin endoperoxide synthases, PGG/H synthases) are potent mediators of edema, impeding blood flow and immunomodulation in the pathologically altered brain. Two COX iso-enzymes have been associated with brain disease, the constitutively expressed COX-1 and the cytokine-inducible COX-2. We have used single and double labeling immunohistochemistry to analyse COX-1 and...

Prostaglandins were discovered in human semen in 1930, but their low concentrations and instability precluded identification for nearly 30 years (for a brief historical review, see Ref. 1). Once they were identified, it was clear they arose from polyunsaturated fatty acids by a complex series of reactions involving oxygenation, cyclization, and the generation of five chiral centers from an achi...

Cyclooxygenase (COX) catalyses the rate-limiting step of prostanoid biosynthesis. Two COX isoforms have been identified, COX-1, the constitutive form, and COX-2, the inducible form. While COX-2 has been implicated in body fat regulation, the underlying cellular mechanism remains to be elucidated. The present study was undertaken to examine the potential role of COX in modulating adipogenesis an...

Generation of vasoactive prostanoids from arachidonic acid by cyclooxygenase (COX)-1 and COX-2 was investigated in anesthetized mice. Intravenous injections of the prostanoid precursor arachidonic acid increased pulmonary arterial pressure and decreased systemic arterial pressure. Pulmonary pressor and systemic depressor responses were attenuated by SC-560 and nimesulide, inhibitors of COX-1 an...