Novel soft matter materials join the resistance of a permanent mesh of strong inter-particle bonds with the self-healing and restructuring properties allowed by bond-swapping processes. Theoretical and numerical studies of the dynamics of coarse-grained models of covalent adaptable networks and vitrimers require effective algorithms for modelling the corresponding evolution of the network topol...

In vitro formation of Hydrogenobacter thermophilus cytochrome c552 has previously been demonstrated (Daltrop, O., Allen, J. W. A., Willis, A. C., and Ferguson, S. J. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 7872-7876). Now we report that the single cysteine variants of H. thermophilus c552, which bind heme via a single thioether bond, also form in vitro. Furthermore, reaction of the apocytoch...

Cytochrome c maturation in the periplasms of many bacteria requires the heme chaperone CcmE, which binds heme covalently both in vivo and in vitro via a histidine residue before transferring the heme to apocytochromes c. To investigate the mechanism and specificity of heme attachment to CcmE, we have mutated the conserved histidine 130 of a soluble C-terminally His-tagged version of CcmE (CcmEs...

ALTHOUGH the incidence of drug allergy in general is low, there are a few drugs which are notable exceptions. For example, Nirvanol, a drug which was once used for treatment of chorea, caused allergic symptoms in nearly every patient (Sherman, 1947). Moreover, among organic molecules which are not of therapeutic value but which are analogous to drugs structurally, many examples can be cited whe...

Mechanical failure of an ideal crystal is dictated either by an elastic instability or a soft-mode instability. Previous interpretations of nanoindentation experiments on suspended graphene sheets,1,2 however, indicate an anomaly: the inferred strain in the graphene sheet directly beneath the diamond indenter at the measured failure load is anomalously large compared to the fracture strains pre...

In humans, there are two subclasses of IgA, IgA1 and IgA2, with IgA2 existing as three allotypes, IgA2m(1), IgA2m(2) and IgA2(n). In IgA1, Cys(133) in C(H)1 forms the disulfide bond to the L chain. Our previous studies indicated that in IgA2 lacking Cys(133), a disulfide bond forms between the alpha-chain and the L chain when Cys(220) is followed by Arg(221), but not when Cys(220) is followed b...

Multicoated magnetite magnetic nanoparticles (MNP) with polyacrylic acid as a terminal hydrophilic ligand showed reproducibility of the composite particles when used draw solution. The tight covalent bond allows MNPs to maintain their osmotic potential after filtration.

Photolysis of ((F)PNP)Pd-Et in the presence of Et(2)Zn leads to the formation of ((F)PNP)Pd-Zn-Pd(PNP(F)), the first example of a compound with a covalent Pd-Zn bond.